The combined effect of MC4R and FTO risk alleles on childhood obesity in Greece
- 10 Downloads
OBJECTIVE: Single nucleotide polymorphism (SNP) risk alleles of obesogenic genes, such as the fat mass and obesity-associated protein (FTO) and the melanocortin-4 receptor (MC4R) gene, have been described in both paediatrics and adult populations. The aim of this study was to investigate the combined effect of FTO and MC4R risk alleles on the obese phenotype and metabolic profile of young children and adolescents of Greek origin. DESIGN: One hundred and fifty-three overweight and obese Greek children (mean age 11.08±2.23 years) and 151 age-matched normal-weight controls were enrolled. Along with anthropometric and standard biochemical profile genetic analysis for the high-risk rs9939609 A allele of the FTO gene and the high-risk C allele of the rs17782313 polymorphism downstream of the MC4R gene were investigated in all participants. RESULTS: The combined presence of three or more high-risk alleles of both the FTO and MC4R genes confers a 4-fold higher risk for obesity in children and adolescents of Greek origin, although these risk alleles have no impact on the metabolic alterations observed in these obese children and adolescents. CONCLUSIONS: There is a synergistic effect of the high-risk alleles of the FTO and MC4R genes on the obese phenotype, while no impact on the metabolic abnormalities was observed in Greek obese children and adolescents.
Key wordsBMI Childhood obesity FTO MC4R Metabolic abnormalities SNP
- 21.Grant SF, Bradfield JP, Zhang H, et al, 2009 Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry. Obesity (Silver Spring) 17: 1461–1465.Google Scholar
- 32.Sovio U, Mook-Kanamori DO, Warrington NM, et al, 2011 Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet 7: e1001307–e07.CrossRefPubMedPubMedCentralGoogle Scholar
- 42.Ortega-Azorín C, Sorlí JV, Asensio EM, et al, 2012 Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovasc Diabetol 11: 137.CrossRefPubMedPubMedCentralGoogle Scholar