, Volume 12, Issue 2, pp 275–282 | Cite as

The effect of prolonged aerobic exercise on serum adipokine levels during an ultra-marathon endurance race

  • Nikolaos D. Roupas
  • Irene Mamali
  • Spyros Maragkos
  • Lydia Leonidou
  • Anastasia K. Armeni
  • George K. Markantes
  • Athanasios Tsekouras
  • George C. Sakellaropoulos
  • Kostas B. Markou
  • Neoklis A. GeorgopoulosEmail author
Research paper


OBJECTIVE: To evaluate the effect of prolonged intensive aerobic exercise and acute energy deficit (180 km ultra-marathon race) on serum leptin, adiponectin, resistin and visfatin levels and their association and interaction with serum cortisol and insulin levels in highly trained ultra-endurance runners. DESIGN: The study included 17 highly trained ultra-endurance male athletes (mean age 51.29±6.84 years and body mass index (BMI) 23.51±1.90) participating in the 5th Olympian Race held in Greece on May 2010. Anthropometric values were assessed; serum cortisol, insulin, leptin, adiponectin, resistin and visfatin levels were measured at baseline, post-exercise and ∼20 hours after the end of the race. RESULTS: All hormonal values of the post-exercise and recovery status were corrected for plasma volume changes. The estimated energy deficit during the ultra-endurance event was about 5000 Kcal. At the end of the race serum resistin levels were elevated (p<0.001) and serum leptin levels were reduced (p<0.001) and failed to reach pre-exercise levels, although showing a tendency towards restoration. No significant changes were noted in serum adiponectin and visfatin levels. CONCLUSIONS: Ultra-endurance aerobic exercise and acute negative energy balance lead to an up-regulation of serum resistin levels and a down-regulation of serum leptin levels.

Key words

Adiponectin Adipose tissue Athlete Leptin Resistin 


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Copyright information

© Hellenic Endocrine Society 2013

Authors and Affiliations

  • Nikolaos D. Roupas
    • 1
  • Irene Mamali
    • 2
  • Spyros Maragkos
    • 3
  • Lydia Leonidou
    • 4
  • Anastasia K. Armeni
    • 1
  • George K. Markantes
    • 1
  • Athanasios Tsekouras
    • 2
  • George C. Sakellaropoulos
    • 5
  • Kostas B. Markou
    • 2
  • Neoklis A. Georgopoulos
    • 1
    Email author
  1. 1.Division of Reproductive Endocrinology, Department of Obstetrics and GynecologyUniversity of Patras Medical School, University HospitalPatrasGreece
  2. 2.Division of Endocrinology, Department of Internal MedicineUniversity of Patras Medical SchoolPatrasGreece
  3. 3.Department of OrthopedicsUniversity of Patras Medical SchoolPatrasGreece
  4. 4.Division of Infectious Diseases, Department of Internal MedicineUniversity of Patras Medical SchoolPatrasGreece
  5. 5.Department of Medical PhysicsUniversity of Patras Medical SchoolPatrasGreece

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