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Hormones

, Volume 12, Issue 2, pp 275–282 | Cite as

The effect of prolonged aerobic exercise on serum adipokine levels during an ultra-marathon endurance race

  • Nikolaos D. Roupas
  • Irene Mamali
  • Spyros Maragkos
  • Lydia Leonidou
  • Anastasia K. Armeni
  • George K. Markantes
  • Athanasios Tsekouras
  • George C. Sakellaropoulos
  • Kostas B. Markou
  • Neoklis A. Georgopoulos
Research paper

Abstract

OBJECTIVE: To evaluate the effect of prolonged intensive aerobic exercise and acute energy deficit (180 km ultra-marathon race) on serum leptin, adiponectin, resistin and visfatin levels and their association and interaction with serum cortisol and insulin levels in highly trained ultra-endurance runners. DESIGN: The study included 17 highly trained ultra-endurance male athletes (mean age 51.29±6.84 years and body mass index (BMI) 23.51±1.90) participating in the 5th Olympian Race held in Greece on May 2010. Anthropometric values were assessed; serum cortisol, insulin, leptin, adiponectin, resistin and visfatin levels were measured at baseline, post-exercise and ∼20 hours after the end of the race. RESULTS: All hormonal values of the post-exercise and recovery status were corrected for plasma volume changes. The estimated energy deficit during the ultra-endurance event was about 5000 Kcal. At the end of the race serum resistin levels were elevated (p<0.001) and serum leptin levels were reduced (p<0.001) and failed to reach pre-exercise levels, although showing a tendency towards restoration. No significant changes were noted in serum adiponectin and visfatin levels. CONCLUSIONS: Ultra-endurance aerobic exercise and acute negative energy balance lead to an up-regulation of serum resistin levels and a down-regulation of serum leptin levels.

Key words

Adiponectin Adipose tissue Athlete Leptin Resistin 

References

  1. 1.
    Mastorakos G, Pavlatou M, Diamanti-Kandarakis E, Chrousos GP, 2005 Exercise and the Stress System. Hormones (Athens) 4: 73–89.Google Scholar
  2. 2.
    Galic S, Oakhilla JS, Steinberg GR, 2010 Adipose tissue as an endocrine organ. Mol Cell Endocrinol 316: 129–139.CrossRefGoogle Scholar
  3. 3.
    Sommer G, Garten A, Petzold S, et al, 2008 Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine. Clin Sci 115: 13–23.CrossRefGoogle Scholar
  4. 4.
    Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z, 2010 Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br J Sport Med 44: 620–630.CrossRefGoogle Scholar
  5. 5.
    Beaumont WV, 1972 Evaluation of hemoconcentration from hematocrit measurements. J Appl Physiol 32: 712–713.CrossRefGoogle Scholar
  6. 6.
    Getzin AR, Milner C, La Face KM, 2011 Nutrition update for the ultraendurance athlete. Curr Sports Med Rep 10: 330–339.CrossRefGoogle Scholar
  7. 7.
    Di Prampero PE, Salvadego D, Fusi S, Grassi B, 2009 A simple method for assessing the energy cost of running during incremental tests. J Appl Physiol 107: 1068–1075.CrossRefGoogle Scholar
  8. 8.
    Jamurtas AZ, Theocharis V, Koukoulis G, et al, 2006 The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males. Eur J Appl Physiol 97: 122–126.CrossRefGoogle Scholar
  9. 9.
    Højbjerre L, Rosenzweig M, Dela F, Bruun JM, Stallknecht B, 2007 Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects. Eur J Endocrinol 157: 613–623.CrossRefGoogle Scholar
  10. 10.
    Varady KA, Bhutani S, Church EC, Phillips SA, 2010 Adipokine responses to acute resistance exercise in trained and untrained men. Med Sci Sports Exerc 42: 456–462.CrossRefGoogle Scholar
  11. 11.
    Wolfe BE, Jimerson DC, Orlova C, Mantzoros CS, 2004 Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers. Clin Endocrinol 61: 332–338.CrossRefGoogle Scholar
  12. 12.
    Dostalova I, Kunesova M, Duskova J, Papezova H, Nedvidkova J, 2006 Adipose tissue resistin levels in patients with anorexia nervosa. Nutrition 22: 977–983.CrossRefGoogle Scholar
  13. 13.
    Fargnoli JL, Sun Q, Olenczuk D, et al, 2010 Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function. Eur J Endocrinol 162: 281–288.CrossRefGoogle Scholar
  14. 14.
    Zaccaria M, Ermolao A, Roi GS, Englaro P, Tegon G, Varnier M, 2002 Leptin reduction after endurance races differing in duration and energy expenditure. Eur J Appl Physiol 87: 108–111.CrossRefGoogle Scholar
  15. 15.
    Leal-Cerro A, Garcia-Luna PP, Astorga R, et al, 1998 Serum leptin levels in male marathon athletes before and after the marathon run. J Clin Endocrinol Metab 83: 2376–2379.PubMedGoogle Scholar
  16. 16.
    Rabe K, Lehrke M, Parhofer KG, Broedl UC, 2008 Adipokines and Insulin Resistance. Mol Med 14: 741–751.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Modan-Moses D, Stein D, Pariente C, et al, 2007 Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients. J Clin Endocrinol Metab 92: 1843–1847.CrossRefGoogle Scholar
  18. 18.
    Saito K, Arata S, Hosono T, et al, 2006 Adiponectin plays an important role in efficient energy usage under energy shortage. Biochim Biophys Acta 1761: 709–716.CrossRefGoogle Scholar
  19. 19.
    Bolduc C, Yoshioka M, St-Amand J, 2010 Acute Molecular Mechanisms Responsive to Feeding and Meal Constitution in Mesenteric Adipose Tissue. Obesity (Silver Spring) 18: 410–413.CrossRefGoogle Scholar
  20. 20.
    Garekani ET, Mohebbi H, Kraemer RR, et al, 2011 Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat. Peptides 32: 1008–1012.CrossRefGoogle Scholar
  21. 21.
    Ghanbari-Niaki A, Saghebjoo M, Soltani R, Kirwan JP, 2010 Plasma visfatin is increased after high-intensity exercise. Ann Nutr Metab 57: 3–8.CrossRefGoogle Scholar
  22. 22.
    Frydelund-Larsen L, Akerstrom T, Nielsen S, Keller P, Keller C, Pedersen BK, 2007 Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise. Am J Physiol Endocrinol Metab 292: E24–E31.CrossRefGoogle Scholar
  23. 23.
    Jürimäe J, Rämson R, Mäestu J, et al, 2009 Plasma visfatin and ghrelin response to prolonged sculling in competitive male rowers. Med Sci Sports Exerc 41: 137–143.CrossRefGoogle Scholar
  24. 24.
    Kang ES, Magkos F, Sienkiewicz E, Mantzoros CS, 2011 Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans. Eur J Endocrinol 164: 911–917.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Sinha MK, Ohannesian JP, Heiman ML, et al, 1996 Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 97: 1344–1347.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Gavrila A, Peng CK, Chan JL, Mietus JE, Goldberger AL, Mantzoros CS, 2003 Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab 88: 2838–2843.CrossRefGoogle Scholar
  27. 27.
    Benedict C, Shostak A, Lange T, et al, 2012 Diurnal rhythm of circulating nicotinamide phosphoribosyltransferase (Nampt/visfatin/PBEF): impact of sleep loss and relation to glucose metabolism. J Clin Endocrinol Metab 97: E218–222.CrossRefGoogle Scholar

Copyright information

© Hellenic Endocrine Society 2013

Authors and Affiliations

  • Nikolaos D. Roupas
    • 1
  • Irene Mamali
    • 2
  • Spyros Maragkos
    • 3
  • Lydia Leonidou
    • 4
  • Anastasia K. Armeni
    • 1
  • George K. Markantes
    • 1
  • Athanasios Tsekouras
    • 2
  • George C. Sakellaropoulos
    • 5
  • Kostas B. Markou
    • 2
  • Neoklis A. Georgopoulos
    • 1
  1. 1.Division of Reproductive Endocrinology, Department of Obstetrics and GynecologyUniversity of Patras Medical School, University HospitalPatrasGreece
  2. 2.Division of Endocrinology, Department of Internal MedicineUniversity of Patras Medical SchoolPatrasGreece
  3. 3.Department of OrthopedicsUniversity of Patras Medical SchoolPatrasGreece
  4. 4.Division of Infectious Diseases, Department of Internal MedicineUniversity of Patras Medical SchoolPatrasGreece
  5. 5.Department of Medical PhysicsUniversity of Patras Medical SchoolPatrasGreece

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