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Hormones

, Volume 11, Issue 3, pp 325–332 | Cite as

Muscle strength and bone in healthy women: effect of age and gonadal status

  • Cristiana Cipriani
  • Elisabetta Romagnoli
  • Vincenzo Carnevale
  • Ida Raso
  • Addolorata Scarpiello
  • Maurizio Angelozzi
  • Andrea Tancredi
  • Stefania Russo
  • Federica De Lucia
  • Jessica Pepe
  • Salvatore Minisola
Research paper

Abstract

OBJECTIVE

The aim of this work was to examine the effects of age and menopause on muscle strength and on the muscle-bone interaction.

DESIGN

One hundred ninety-four healthy women (mean age 49.8 ± 12.6 SD years) were assessed. Maximal Voluntary Contraction (MVC, Newton, N) by Hand Grip Dynamometer, bone mineral density at one third of the radius (R-BMD) by dual-energy X-ray absorptiometry (DXA) and phalangeal ultrasound by the DBM Sonic 1200 device were evaluated at the upper dominant limb. Ultrasonometric parameters considered were Amplitude-Dependent Speed of Sound (ADSoS) and Ultrasound Bone Profile Index (UBPI).

RESULTS

MVC significantly decreased with age (r2=−0.12, p<0.005). For each level of age, fertile women had a greater MVC compared to postmenopausal women (r2=0.015, p<0.005). In the whole sample, a statistically significant correlation between MVC and R-BMD (r=0.354, p<0.001) and between MVC and ADSoS (r=0.294) and UBPI (r=0.311)(p<0.001 for both) were observed.

CONCLUSIONS

We conclude that age and menopausal status significantly contributed to the reduction of muscle strength. The decline of muscular strength significantly correlated with quantitative and qualitative bone features.

Key words

Age Bone Menopause Muscle Strength 

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Copyright information

© Hellenic Endocrine Society 2012

Authors and Affiliations

  • Cristiana Cipriani
    • 1
  • Elisabetta Romagnoli
    • 1
  • Vincenzo Carnevale
    • 2
  • Ida Raso
    • 1
  • Addolorata Scarpiello
    • 1
  • Maurizio Angelozzi
    • 1
  • Andrea Tancredi
    • 3
  • Stefania Russo
    • 1
  • Federica De Lucia
    • 1
  • Jessica Pepe
    • 1
  • Salvatore Minisola
    • 1
  1. 1.Department of Internal Medicine and Medical DisciplinesUniversity of Rome “Sapienza”RomeItaly
  2. 2.Unit of Internal MedicineIstituto di Ricovero e Cura a Carattere Scientifico “Casa Sollievo della Sofferenza” HospitalSan Giovanni RotondoItaly
  3. 3.Department of Methods and Models for Economics, Territory and FinanceUniversity of Rome “Sapienza”RomeItaly

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