, Volume 11, Issue 3, pp 325–332 | Cite as

Muscle strength and bone in healthy women: effect of age and gonadal status

  • Cristiana CiprianiEmail author
  • Elisabetta Romagnoli
  • Vincenzo Carnevale
  • Ida Raso
  • Addolorata Scarpiello
  • Maurizio Angelozzi
  • Andrea Tancredi
  • Stefania Russo
  • Federica De Lucia
  • Jessica Pepe
  • Salvatore Minisola
Research paper



The aim of this work was to examine the effects of age and menopause on muscle strength and on the muscle-bone interaction.


One hundred ninety-four healthy women (mean age 49.8 ± 12.6 SD years) were assessed. Maximal Voluntary Contraction (MVC, Newton, N) by Hand Grip Dynamometer, bone mineral density at one third of the radius (R-BMD) by dual-energy X-ray absorptiometry (DXA) and phalangeal ultrasound by the DBM Sonic 1200 device were evaluated at the upper dominant limb. Ultrasonometric parameters considered were Amplitude-Dependent Speed of Sound (ADSoS) and Ultrasound Bone Profile Index (UBPI).


MVC significantly decreased with age (r2=−0.12, p<0.005). For each level of age, fertile women had a greater MVC compared to postmenopausal women (r2=0.015, p<0.005). In the whole sample, a statistically significant correlation between MVC and R-BMD (r=0.354, p<0.001) and between MVC and ADSoS (r=0.294) and UBPI (r=0.311)(p<0.001 for both) were observed.


We conclude that age and menopausal status significantly contributed to the reduction of muscle strength. The decline of muscular strength significantly correlated with quantitative and qualitative bone features.

Key words

Age Bone Menopause Muscle Strength 


  1. 1.
    Ling CH, Taekema D, de Craen AJ, Gussekloo J, Westendorp RG, Maier AB, 2010 Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. CMAJ 182: 429–435.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Samuel D, Rowe PJ, 2009 Effect of ageing on isometric strength through joint range at knee and hip joints in three age groups of older adults. Gerontology 55: 621–629.CrossRefGoogle Scholar
  3. 3.
    Di Monaco M, Vallero F, Di Monaco R, Tappero R, 2011 Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture. Arch Gerontol. Geriatr 52: 71–74.CrossRefGoogle Scholar
  4. 4.
    Janssen I, Heymsfield SB, Ross R, 2002 Low relative skeletal muscle mass (Sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50: 889–896.CrossRefGoogle Scholar
  5. 5.
    Janssen HC, Samson MM, Verhaar HJ, 2002 Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nut 75: 611–615.CrossRefGoogle Scholar
  6. 6.
    Iannuzzi-Sucich M, Prestwood KM, Kenny AM, 2002 Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 57: 772–777.CrossRefGoogle Scholar
  7. 7.
    Visvanathan R, Chapman I, 2010 Preventing sarcopaenia in older people. Maturitas 66: 383–388.CrossRefGoogle Scholar
  8. 8.
    Maltais ML, Desroches J, Dionne IJ, 2009 Changes in muscle mass and strength after menopause. J Musculoskelet Neuronal Interact. 9: 186–197.PubMedGoogle Scholar
  9. 9.
    Walsh MC, Hunter GR, Livingstone MBM, 2006 Sarcopenia in premenopausal and postmenopausal women with osteopenia, osteoporosis and normal bone mineral density. Osteoporos Int 17: 61–67.CrossRefGoogle Scholar
  10. 10.
    Samuel D, Rowe PJ, 2009 Effect of ageing on isometric strength trough joint range at knee and hip joints in three age groups of older adults. Gerontology 55: 621–629.CrossRefGoogle Scholar
  11. 11.
    Daly RM, Ahlborg HG, Ringsberg K, Gardsell P, Sernbo I, Karlsson MK, 2008 Association between changes in habitual physical activity and changes in bone density, muscle strength, and functional performance in elderly men and women. J Am Geriatr Soc 56: 2252–2260.CrossRefGoogle Scholar
  12. 12.
    Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al, 2010 European Working Group on Sarcopenia in Older People Sarcopenia: European consensus on definition and diagnosis. Age Ageing 39: 412–423.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Hamrick MW, Samaddar T, Pennington C, McCormick J, 2006 Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise. J Bone Miner Res 21: 477–483.CrossRefGoogle Scholar
  14. 14.
    Dixon WG, Lunt M, Pye SR, et al, 2005 European Prospective Osteoporosis Study Group Low grip strength is associated with bone mineral density and vertebral fracture in women. Rheumatology (Oxford) 44: 642–646.CrossRefGoogle Scholar
  15. 15.
    Marin RV, Pedrosa MA, Moreira-Pfrimer LD, Matsudo SM, Lazaretti-Castro M, 2010 Association between lean mass and handgrip strength with bone mineral density in physically active postmenopausal women. J Clin Densitom 13: 96–101.CrossRefGoogle Scholar
  16. 16.
    Frost HM, 1997 Perspective: On our age-related bone loss: Insights from a new paradigm. J Bone Miner Res 12: 1539–1546.CrossRefGoogle Scholar
  17. 17.
    Blain H, Vuillemin A, Teissier A, Hanesse B, Guillemin F, Jeandel C, 2001 Influence of muscle strength and body weight and composition on regional bone mineral density in healthy women aged 60 years and over. Gerontology 47: 207–212.CrossRefGoogle Scholar
  18. 18.
    Di Monaco M, Di Monaco R, Manca M, Cavanna A, 2000 Handgrip strength is an independent predictor of distal radius bone mineral density in postmenopausal women. Clin Rheumatol 19: 473–476.CrossRefGoogle Scholar
  19. 19.
    Albrand G, Munoz F, Sornay-Rendu E, DuBoeuf F, Delmas PD, 2003 Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: The OFELY Study. Bone 32: 78–85.CrossRefGoogle Scholar
  20. 20.
    Cipriani C, Romagnoli E, Scarpiello A, Angelozzi M, Montesano T, Minisola S, 2009 Phalangeal quantitative ultrasound and bone mineral density in evaluating cortical bone loss: a study in postmenopausal women with primary hyperparathyroidism and subclinical iatrogenic hyperthyroidism. J Clin Densitom 12: 456–460.CrossRefGoogle Scholar
  21. 21.
    Lauretani F, Russo CR, Bandinelli S, et al, 2003 Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol 95: 1851–1860.CrossRefGoogle Scholar
  22. 22.
    Frontera WR, Hughes VA, Lutz KJ, Evans WJ, 1991 A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women. J Appl Physiol 71: 644–650.CrossRefGoogle Scholar
  23. 23.
    Brown M, 2008 Skeletal muscle and bone: effect of sex steroids and aging. Adv Physiol Educ 32: 120–126.CrossRefGoogle Scholar
  24. 24.
    Lee CE, McArdle A, Griffiths RD, 2007 The role of hormones, cytokines and heat shock proteins during age-related muscle loss. Clin Nutr 26: 524–534.CrossRefGoogle Scholar
  25. 25.
    Evans WJ, Campbell WW, 1993 Sarcopenia and Age-related changes in body composition and functional capacity. J Nutr 123: Suppl 2: 465–468.CrossRefGoogle Scholar
  26. 26.
    Rolland YM, Perry HM 3rd, Patrick P, Banks WA, Morley JE, 2007 Loss of appendicular muscle mass and loss of muscle strength in young postmenopausal women. J Gerontol A Biol Sci Med Sci 62: 330–335.CrossRefGoogle Scholar
  27. 27.
    Wiik A, Ekman M, Johansson O, Jansson E, Esbjörnsson M, 2009 Expression of both oestrogen receptor alpha and beta in human skeletal muscle tissue. Cell Biol Histochem 131: 181–189.CrossRefGoogle Scholar
  28. 28.
    Frank AW, Lorbergs AL, Chilibeck PD, Farthing JP, Kontulainen SA, 2010 Muscle cross sectional area and grip torque contraction types are similarly related to pQCT derived bone strength indices in the radii of older healthy adults. J Musculoskelet Neuronal Interact 10: 136–141.PubMedGoogle Scholar
  29. 29.
    Sherk VD, Palmer IJ, Bemben MG, Bemben DA, 2009 Relationships between body composition, muscular strength, and bone mineral density in estrogen-deficient postmenopausal women. J Clin Densitom 12: 292–298.CrossRefGoogle Scholar
  30. 30.
    Frost HM, 2001 From Wolff’s Law to the Utah paradigm: insights about bone physiology and its clinical applications. Anat Rec. 262: 398–419.CrossRefGoogle Scholar
  31. 31.
    Kaji H, Kosaka R, 2005 Effects of age, grip strength and smoking on forearm volumetric bone mineral density and bone geometry by peripheral quantitative computed tomography: Comparisons between female and male. Endocr J 52: 659–666.CrossRefGoogle Scholar
  32. 32.
    Snow-Harter C, Bouxsein M, Lewis B, Charette S, Weinstein P, Marcus R, 1990 Muscle strength as a predictor of bone mineral density in young women. J Bone Miner Res 5: 589–595.CrossRefGoogle Scholar
  33. 33.
    Burr DB, 1997 Muscle strength, bone mass, and age-related bone loss. J Bone Miner Res 12: 1547–1551.CrossRefGoogle Scholar
  34. 34.
    Taaffe DR, Cauley JA, Danielson M, et al, 2001 Race and sex effects on the association between muscle strength, soft tissue, and bone mineral density in healthy elders: the Health, Aging, and Body Composition Study. J Bone Miner Res 16: 1343–1352.CrossRefGoogle Scholar
  35. 35.
    Marques EA, Mota J, Machado L, et al, 2010 Multicomponent training program with weight-bearing exercises elicits favorable bone density, muscle strength, and balance adaptations in older women. Calcif Tissue Int 88: 117–129.CrossRefGoogle Scholar
  36. 36.
    Howe TE, Shea B, Dawson LJ, et al, 2011 Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev 6: CD000333.Google Scholar
  37. 37.
    Chan K, Qin L, Lau M, et al, 2004 A randomised prospective study of the effects of Tai ChiChun exercise on bone mineral density in postmenopausal women. Arch Phys Med Rehabil 85: 717–722.CrossRefGoogle Scholar
  38. 38.
    Wayne PM, Kiel DP, Buring JE, et al, 2012 Impact of Tai Chi exercise on multiple fracture-related risk factors in post-menopausal osteopenic women: a pilot pragmatic, randomized trial. BMC Complement Altern Med 12: 7.CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Lang TF, 2011 The bone-muscle relationship in men and women. J Osteoporos 2011: 702735.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Kukuljan S, Nowson CA, Sanders KM, et al, 2011 Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial. J Clin Endocrinol Metab 96: 955–963.CrossRefGoogle Scholar
  41. 41.
    Guadalupe-Grau A, Fuentes T, Guerra B, Calbet JA, 2009 Exercise and bone mass in adults. Sports Med 39: 439–468.CrossRefGoogle Scholar

Copyright information

© Hellenic Endocrine Society 2012

Authors and Affiliations

  • Cristiana Cipriani
    • 1
    Email author
  • Elisabetta Romagnoli
    • 1
  • Vincenzo Carnevale
    • 2
  • Ida Raso
    • 1
  • Addolorata Scarpiello
    • 1
  • Maurizio Angelozzi
    • 1
  • Andrea Tancredi
    • 3
  • Stefania Russo
    • 1
  • Federica De Lucia
    • 1
  • Jessica Pepe
    • 1
  • Salvatore Minisola
    • 1
  1. 1.Department of Internal Medicine and Medical DisciplinesUniversity of Rome “Sapienza”RomeItaly
  2. 2.Unit of Internal MedicineIstituto di Ricovero e Cura a Carattere Scientifico “Casa Sollievo della Sofferenza” HospitalSan Giovanni RotondoItaly
  3. 3.Department of Methods and Models for Economics, Territory and FinanceUniversity of Rome “Sapienza”RomeItaly

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