, Volume 11, Issue 3, pp 316–324 | Cite as

The effect of a non-intensive community-based lifestyle intervention on the prevalence of Metabolic Syndrome. The DEPLAN study in Greece

  • Konstantinos MakrilakisEmail author
  • Sofia Grammatikou
  • Stavros Liatis
  • Meropi Kontogianni
  • Despoina Perrea
  • Charilaos Dimosthenopoulos
  • Kalliopi-Anna Poulia
  • Nicholas Katsilambros
Research paper



The aim of the present study was to evaluate the effectiveness of a non-intensive, community-based, lifestyle intervention program on the prevalence of metabolic syndrome (MS), in individuals at high risk for development of type 2 diabetes (T2D).


In accordance with the FINDRISC score, 191 high-risk persons for T2D, 56.3±10.8 years old, participated in a one-year lifestyle intervention program consisting of six bi-monthly sessions with a dietician. MS prevalence was assessed at baseline and one year later.


The intervention was completed by 125 participants. They lost on average 1.0±4.8 kg (p=0.025) (mean±SD) and registered favourable dietary changes. The baseline prevalence of MS was similar among age groups and genders and decreased after one year (from 63.4±48.4% to 54.8±50.0%, p<0.001). In a multiple logistic regression model, younger age (p=0.009), male gender (p=0.004), improvement of the dietary score after one year (p=0.022), a lower FINDRISC score (p=0.033), a lower triglyceride level (p=0.010) and a higher baseline HDL-C level (p=0.003) were significantly and independently associated with improvement in MS status.


A non-intensive lifestyle intervention program to prevent T2D is effective in decreasing the prevalence of MS in individuals at high risk for T2D development, possibly conferring multiple cardiovascular health benefits.

Key words

Lifestyle intervention Metabolic syndrome Type 2 diabetes prevention 


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Copyright information

© Hellenic Endocrine Society 2012

Authors and Affiliations

  • Konstantinos Makrilakis
    • 1
    Email author
  • Sofia Grammatikou
    • 1
  • Stavros Liatis
    • 1
  • Meropi Kontogianni
    • 2
  • Despoina Perrea
    • 3
  • Charilaos Dimosthenopoulos
    • 1
  • Kalliopi-Anna Poulia
    • 1
  • Nicholas Katsilambros
    • 1
  1. 1.First Department of Propaedeutic Medicine, Athens University Medical SchoolLaiko General HospitalAthensGreece
  2. 2.Department of Nutrition & DieteticsHarokopio UniversityGreece
  3. 3.Laboratory for Experimental Surgery and Surgical Research “Christeas Hall”University of Athens Medical SchoolAthensGreece

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