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Hormones

, Volume 11, Issue 3, pp 290–296 | Cite as

Somatostatin receptor expression in non-medullary thyroid carcinomas

  • Kalliopi Pazaitou-Panayiotou
  • Eva Tiensuu Janson
  • Triantafyllia Koletsa
  • Vassiliki Kotoula
  • Mats Stridsberg
  • Georgios Karkavelas
  • Georgia Karayannopoulou
Research paper

Abstract

OBJECTIVE

Peptide receptor radionuclide therapy (PRRT) is dependent upon binding of radiolabelled peptides to their respective receptor expressing cells. The main objective of this study was to characterize the expression of somatostatin receptor (SSTR) subtypes in non-medullary thyroid cancers in order to be able to recommend the use of PRRT as a treatment option in patients with progressive local or metastatic disease.

DESIGN

We constructed tissue microarrays from paraffin blocks prepared from 47 cases of non-medullary thyroid carcinomas and related normal thyroid tissue. Immunohistochemical staining was performed with five different polyclonal SSTR antibodies.

RESULTS

SSTR subtypes sst2 and sst3 were expressed in all non-medullary thyroid carcinomas, sst1 and sst5 in 75%, and sst4 in 38%. Coexpression of more than three subtypes was detected in 36 of the 47 cases. The expression of SSTR sub-types in normal thyroid tissue was low or absent.

CONCLUSIONS

Non-medullary thyroid carcinomas frequently express all SSTR subtypes. This expression provides a basis for further studies with the aim of exploring PRRT as a possible new treatment for iodine-131 refractory metastatic non-medullary thyroid carcinomas.

Key words

Thyroid carcinoma Somatostatin receptor Tissue microarray Immunohistochemistry 

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Copyright information

© Hellenic Endocrine Society 2012

Authors and Affiliations

  • Kalliopi Pazaitou-Panayiotou
    • 1
  • Eva Tiensuu Janson
    • 2
  • Triantafyllia Koletsa
    • 3
  • Vassiliki Kotoula
    • 3
  • Mats Stridsberg
    • 4
  • Georgios Karkavelas
    • 3
  • Georgia Karayannopoulou
    • 3
  1. 1.Department of Endocrinology - Endocrine OncologyTheagenio Cancer HospitalThessalonikiGreece
  2. 2.Department of Medical Sciences, Endocrine OncologyUppsala UniversityUppsalaSweden
  3. 3.Department of Pathology, Medical SchoolAristotle University of ThessalonikiThessalonikiGreece
  4. 4.Department of Medical Sciences, Clinical ChemistryUppsala UniversityUppsalaSweden

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