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Auraptene in the Peels of Citrus Kawachiensis (Kawachibankan) Contributes to the Preservation of Cognitive Function: A Randomized, Placebo-Controlled, Double-Blind Study in Healthy Volunteers

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Abstract

Objectives

Dementia, which is characterized by a progressive decline in cognitive function, is a major concern in aging societies. Although a number of treatments have been approved, an effective therapy to prevent the disorder is lacking. A supplement that improves cognitive function would benefit patients. The aim of this study was to assess whether auraptene, a citrus coumarin, has a protective effect on cognitive decline.

Design

A randomized, placebo-controlled, double-blind study

Setting

Outpatient medical check-up program for cognitive disorders

Participants

84 adult volunteers (they are cognitively normal) met inclusion and exclusion criteria to participate.

Intervention

42 participants received auraptene enriched (containing 6.0 mg/day of auraptene) test juice, and another participants received placebo juice.

Measurements

1) Mild Cognitive Impairment (MCI) Screen using the 10-word immediate recall test. 2) The Mini-Mental State Examination (MMSE). Cognitive assessment ware carried out baseline and at 24 weeks.

Results

Auraptene enriched test juice did not improve cognitive function after 24 weeks compared with baseline data. However, there was a significant difference in the percentage change in cognitive function between the test and placebo orange juice groups (6.3 ± 18.9 vs. −2.4 ± 14.8, P < 0.05). Multiple regression analysis demonstrated a significant independent relationship between the percentage change in the 10-word immediate recall test score and test juice consumption including baseline 10-word immediate recall test score in all subjects.

Conclusion

This is the first study to assess the effectiveness of auraptene in the prevention of cognitive decline. Our results suggest that auraptene is a safe supplement for the prevention of cognitive decline.

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Authors and Affiliations

  1. Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon City, Ehime, 791-0295, Japan

    Michiya Igase, Y. Okada, M. Ochi, H. Ochi & Y. Ohyagi

  2. Department of Advanced Neurosurgery, Ehime University Graduate School of Medicine, Ehime, Japan

    K. Igase

  3. Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, Ehime, Japan

    S. Okuyama & Y. Furukawa

Authors
  1. Michiya Igase
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  2. Y. Okada
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  3. M. Ochi
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  4. K. Igase
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  5. H. Ochi
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  6. S. Okuyama
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  7. Y. Furukawa
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  8. Y. Ohyagi
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Corresponding author

Correspondence to Michiya Igase.

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Igase, M., Okada, Y., Ochi, M. et al. Auraptene in the Peels of Citrus Kawachiensis (Kawachibankan) Contributes to the Preservation of Cognitive Function: A Randomized, Placebo-Controlled, Double-Blind Study in Healthy Volunteers. J Prev Alzheimers Dis 5, 197–201 (2018). https://doi.org/10.14283/jpad.2017.47

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  • DOI: https://doi.org/10.14283/jpad.2017.47

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