Abstract
Introduction
Understanding the intersection of HIV, aging and health is crucial due to the increasing number of people aging with HIV.
Objective
The objective of the study was to assess the prevalence of, and risk factors for individual comorbidities and multi-morbidity in people living with HIV with similar duration of HIV infection, notwithstanding a 25-year difference at the time of HIV acquisition.
Methods
In a crosssectional multicentre retrospective study, we compared three match-control age groups. The “Young” were selected from Romania and included HIV-positive patients prenatally infected and assessed at the age of 25–30 years. The “Old” and the “Geriatric” were selected from Italy. These respectively included subjects infected with HIV at the age of 25 years and assessed at the age of 50–55 years, and those infected at the age of 50 years and assessed at the age of 75–80 years. Each group was sex and age matched in a 1:5 ratio with controls selected from the CINECA ARNO database from Italy. We described non-infectious comorbidities (NICM), including cardiovascular disease, hypertension, dyslipidaemia, diabetes, chronic kidney disease, and multi-morbidity (MM= 3 NICM).
Results
MM prevalence in the “Young” group compared to controls was 6.2% vs 0%, while in the “Geriatric” was “68.2% vs 3.6%. Using “Young” as a reference, in multivariate analyses, predictors for MM were as follows: HIV serostatus (OR=47.75, IQR 14.78-154.25, p<0.01) and “Geriatric” vs “Young” (OR=30.32, IQR 5.89-155.98, p<0.01).
Conclusion
These data suggest that age at acquisition of HIV should be considered as a risk factor for NICM and MM.
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Guaraldi, G., Malagoli, A., Milic, J. et al. Age of HIV Acquisition Affects the Risk of Multi-Morbidity After 25 Years of Infection Exposure. J Frailty Aging 8, 88–92 (2019). https://doi.org/10.14283/jfa.2019.6
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DOI: https://doi.org/10.14283/jfa.2019.6