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Is a Large-Scale Screening for Alzheimer’s Disease Possible? Yes, in a Few Years

  • F. Ribaldi
  • Daniele AltomareEmail author
  • G. B. Frisoni
Commentary

Recent evidence on blood-based biomarkers is pointing the way towards a new era of large-scale, feasible, cost-effective and non-invasive screening for Alzheimer’s disease (AD). This was one of the main focuses of the recent meeting of the European Union-North American Clinical Trials in AD (EU/US CTAD) Task Force, which took place in Barcelona in October 24–27, 2018, and convened drug and diagnostics developers from industry and academia in order to define a roadmap for the development and marketing of blood-based biomarkers (1).

According to the recent National Institute on Aging - Alzheimer’s Association (NIA-AA) and International Working Group (IWG-2) diagnostic criteria (2’4), AD biomarkers can be assessed using neuroimaging techniques (i.e. magnetic resonance, MR; and positron emission tomography, PET) and/or cerebrospinal fluid (CSF) collection, and include amyloid (PET or CSF), tau (PET or CSF) and neurodegeneration (MR, PET, or CSF). Among them, only MR is usually performed...

Notes

Conflict of interest: Dr. Ribaldi and Dr. Altomare have nothing to disclose. Dr. Frisoni reports grants from Alzheimer Forum Suisse, grants from Académie Suisse des Sciences Médicales (ASSM), grants from Avid Radiopharmaceuticals, grants from Biogen, grants from GE International, grants from Guerbert, grants from IFRAD Suisse (Association Suisse pour la Recherche sur l’Alzheimer), grants from Ixico, grants from Merz, grants from Nestlé, grants from Novartis, grants from Piramal, grants from Roche, grants from Siemens, grants from Teva Pharma, grants from Vifor Pharma, grants from Alzheimer’s Association, personal fees from AstraZeneca, personal fees from Avid Radiopharmaceuticals, personal fees from Elan, personal fees from GE International, personal fees from Lundbeck, personal fees from Pfizer, personal fees from Taurx, outside the submitted work.

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Copyright information

© Serdi and Springer Nature Switzerland AG 2019

Authors and Affiliations

  • F. Ribaldi
    • 1
    • 2
    • 3
  • Daniele Altomare
    • 1
    • 4
    Email author
  • G. B. Frisoni
    • 1
    • 4
  1. 1.Laboratory of Neuroimaging of Aging (LANVIE)University of GenevaGenevaSwitzerland
  2. 2.Laboratory of Alzheimer’s Neuroimaging and Alzheimer’s Epidemiology (LANE)IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliBresciaItaly
  3. 3.University of Brescia, Department of Molecular and Translational MedicineBresciaItaly
  4. 4.Memory ClinicUniversity Hospital of GenevaGenevaSwitzerland

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