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Theme: Clinical Trials Methodology

P21: Patterns of Mmse Subtest Scores in Amyloid-Positive and -Negative Participants In J-Adni. Ryoko Ihara1, Kazushi Suzuki1, Atsushi Iwata2, Takeshi Iwatsubo1,3, the Japanese Alzheimer’s Disease Neuroimaging Initiative ((1) The Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo -Japan; (2) Department of Neurology, The University of Tokyo, Tokyo -Japan; (3) Department of Neuropathology, The University of Tokyo, Tokyo – Japan)

Backgrounds: The MMSE is commonly used both in clinical research and in clinical practice. As the MMSE is composed of subtests for multiple cognitive domains, namely, orientation, memory, attention, language and visuospatial function; thus, it tells more than the total score which briefly indicates the severity of cognitive impairment. Objectives: Therefore, we analyzed the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) data to clarify how subscores of the MMSE differ...

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