WHO Guidelines on Community-Level Interventions to Manage Declines in Intrinsic Capacity: The Road to Prevention Cognitive Decline in Older Age?

  • B. VellasEmail author
  • D. Scrase
  • G. A. Rosenberg
  • S. Andrieu
  • I. Araujo de Carvalho
  • L. T. Middleton


  1. 1.
    WHO Clinical Consortium on Healthy Ageing 2017–report of consortium meeting 21 and 22 November 2017 in Geneva, Switzerland. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO.Google Scholar
  2. 2.
    Cesari M1,2,3,4, Araujo de Carvalho I5, Amuthavalli Thiyagarajan J5, Cooper C6, Martin FC7, Reginster JY8, Vellas B1,2, Beard JR5. Evidence for The Domains Supporting The Construct of Intrinsic Capacity. J Gerontol A Biol Sci Med Sci. 2018 Feb 2. doi: 10.1093/gerona/gly011. [Epub ahead of print]Google Scholar
  3. 3.
    Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Jun 6;385(9984):2255–63. doi:10.1016/S0140-6736(15)60461-5. Epub 2015 Mar 12. PubMed PMID: 25771249.CrossRefPubMedGoogle Scholar
  4. 4.
    Andrieu S(1), Guyonnet S(2), Coley N(3), Cantet C(2), Bonnefoy M(4), Bordes S(5), Bories L(6), Cufi MN(7), Dantoine T(8), Dartigues JF(9), Desclaux F(10), Gabelle A(11), Gasnier Y(5), Pesce A(12), Sudres K(13), Touchon J(14), Robert P(15), Rouaud O(16), Legrand P(17), Payoux P(18), Caubere JP(19), Weiner M(20), CarriéI, Ousset PJ(2), Vellas B(2); MAPT Study Group. Effect of longterm omega 3 polyunsaturated fatty acid supplementation with orwithout multidomain intervention on cognitive function in elderly adults withmemory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017 May;16(5):377–389. doi: 10.1016/S1474-4422(17)30040-6. Epub 2017 Mar 27.CrossRefGoogle Scholar
  5. 5.
    Barbera M, Mangialasche F, Jongstra S, Guillemont J, Ngandu T, Beishuizen C, Coley N, Brayne C, Andrieu S, Richard E, Soininen H, Kivipelto M; HATICE study group. Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults: The HATICE Trial. J Alzheimers Dis. 2018;62(2):649–663. doi: 10.3233/JAD-170858. PubMed PMID: 29480185.CrossRefPubMedGoogle Scholar
  6. 6.
    Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, Iqbal K, Jessen F, Johansson G, Jönsson L, Kivipelto M, Knapp M, Mangialasche F, Melis R, Nordberg A, Rikkert MO, Qiu C, Sakmar TP, Scheltens P, Schneider LS, Sperling R, Tjernberg LO, Waldemar G, Wimo A, Zetterberg H. Defeating Alzheimer’s disease and other dementias: a priority for European science and society. Lancet Neurol. 2016 Apr;15(5):455–532. doi: 10.1016/S1474-4422(16)00062-4. Review.CrossRefPubMedGoogle Scholar
  7. 7.
    Michel J.-P. Mobile application removes societal barriers to P4 medicine. J Frailty Aging. 2017;6(4):216–218. doi: 10.14283/jfa.2017.43.PubMedGoogle Scholar
  8. 8.
    Qualls C, Waters DL, Vellas B, Villareal DT, Garry PJ, Gallini A, Andrieu S. Reversible States of Physical and/or Cognitive Dysfunction: A 9-Year Longitudinal Study. J Nutr Health Aging. 2017;21(3):271–275. doi: 10.1007/s12603-017-0878-3 PubMed PMID: 28244566.NMAPSCrossRefPubMedGoogle Scholar
  9. 9.
    Donohue MC, Sperling RA, Salmon DP, Rentz DM, Raman R, Thomas RG, Weiner M, Aisen PS. Australian Imaging, Biomarkers, and Lifestyle Flagship Study of Ageing;Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Cooperative Study. The preclinical Alzheimer cognitive composite: measuring amyloid-related decline. JAMA Neurol. 2014 Aug;71(8):961–70. doi: 10.1001/jamaneurol.2014.803. PubMed PMID: 24886908; PubMed Central PMCID: PMC4439182.PubMedGoogle Scholar

Copyright information

© Serdi and Springer Nature Switzerland AG 2018

Authors and Affiliations

  • B. Vellas
    • 1
    Email author
  • D. Scrase
    • 2
  • G. A. Rosenberg
    • 3
  • S. Andrieu
    • 4
  • I. Araujo de Carvalho
    • 5
  • L. T. Middleton
    • 6
  1. 1.Gerontopole, W.H.O Collaborative Center for FrailtyCHU PurpanToulouseFrance
  2. 2.Section of Geriatrics, Department of Internal MedicineUNMAlbuquerqueUSA
  3. 3.Memory and Aging Center, Department of NeurologyUNMAlbuquerqueUSA
  4. 4.Department of Public Health, UMR INSERM 1027UPS-CHU ToulouseToulouseFrance
  5. 5.World Health OrganisationGenevaSwitzerland
  6. 6.School of Public HealthImperial CollegeLondonUK

Personalised recommendations