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What Have We Learned from Expedition III and EPOCH Trials? Perspective of the CTAD Task Force

  • P. S. Aisen
  • E. Siemers
  • D. Michelson
  • S. Salloway
  • C. Sampaio
  • M. C. Carrillo
  • R. Sperling
  • R. Doody
  • P. Scheltens
  • R. Bateman
  • M. Weiner
  • B. Vellas
  • EU/US/CTAD Task Force members
CTAD Task Force Paper
  • 41 Downloads

Abstract

Although the results were disappointing from two recent clinical trials of amyloid-targeting drugs in mild-to-moderate AD, the trials provided information that will be important for future studies, according to the EU-US CTAD Task Force, which met in November 2017 to discuss the EXPEDITION3 and EPOCH trials. These trials tested two of the predominant drug development strategies for AD: amyloid immunotherapy and BACE inhibition in populations largely composed of mild AD dementia patients. The results of these trials support the emerging consensus that effective amyloid-targeted treatment will require intervention in early, even pre-symptomatic stages of the disease. Further, the Task Force suggested that a refinement of the amyloid hypothesis may be needed and that other hypotheses should be more fully explored. In addition, they called for improved biomarkers and other outcome assessments to detect the earliest changes in the development of AD.

Key words

Alzheimer’s disease therapeutic trials 

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Copyright information

© Serdi and Springer Nature Switzerland AG 2018

Authors and Affiliations

  • P. S. Aisen
    • 1
    • 13
  • E. Siemers
    • 2
  • D. Michelson
    • 3
  • S. Salloway
    • 4
  • C. Sampaio
    • 5
  • M. C. Carrillo
    • 6
  • R. Sperling
    • 7
  • R. Doody
    • 8
  • P. Scheltens
    • 9
  • R. Bateman
    • 10
  • M. Weiner
    • 11
  • B. Vellas
    • 12
  • EU/US/CTAD Task Force members
  1. 1.Alzheimer’s Therapeutic Research Institute (ATRI), Keck School of MedicineUniversity of Southern CaliforniaSan DiegoUSA
  2. 2.Eli Lilly and CompanyIndianapolisUSA
  3. 3.Merck, Inc.KenilworthUSA
  4. 4.The Warren Alpert Medical School of Brown UniversityProvidenceUSA
  5. 5.CHDI FoundationPrincetonUSA
  6. 6.Alzheimer’s AssociationChicagoUSA
  7. 7.Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  8. 8.F. Hoffmann-LaRoche Ltd.BaselSwitzerland
  9. 9.VU University Medical CenterAmsterdamThe Netherlands
  10. 10.Washington University School of MedicineSt. LouisUSA
  11. 11.University of CaliforniaSan FranciscoUSA
  12. 12.Gerontopole, INSERM U1027, Alzheimer’s Disease Research and Clinical CenterToulouse University HospitalToulouseFrance
  13. 13.University of Southern California Alzheimer’s Therapeutic Research InstituteSan DiegoUSA

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