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Increased Functional Connectivity After Listening to Favored Music in Adults With Alzheimer Dementia

  • J. B. King
  • K. G. Jones
  • E. Goldberg
  • M. Rollins
  • K. MacNamee
  • C. Moffit
  • S. R. Naidu
  • M. A. Ferguson
  • E. Garcia-Leavitt
  • J. Amaro
  • K. R. Breitenbach
  • J. M. Watson
  • R. K. Gurgel
  • Jeffrey S. Anderson
  • N. L. Foster
Original Research
  • 5 Downloads

Abstract

Background

Personalized music programs have been proposed as an adjunct therapy for patients with Alzheimer disease related dementia, and multicenter trials have now demonstrated improvements in agitation, anxiety, and behavioral symptoms. Underlying neurophysiological mechanisms for these effects remain unclear.

Methods

We examined 17 individuals with a clinical diagnosis of Alzheimer disease related dementia using functional MRI following a training period in a personalized music listening program.

Results

We find that participants listening to preferred music show specific activation of the supplementary motor area, a region that has been associated with memory for familiar music that is typically spared in early Alzheimer disease. We also find widespread increases in functional connectivity in corticocortical and corticocerebellar networks following presentation of preferred musical stimuli, suggesting a transient effect on brain function.

Conclusions

Findings support a mechanism whereby attentional network activation in the brain’s salience network may lead to improvements in brain network synchronization.

Key words

Personalized music dementia supplementary motor area fMRI functional connectivity 

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Copyright information

© Serdi and Springer Nature Switzerland AG 2018

Authors and Affiliations

  • J. B. King
    • 1
    • 2
  • K. G. Jones
    • 1
  • E. Goldberg
    • 3
  • M. Rollins
    • 2
  • K. MacNamee
    • 4
  • C. Moffit
    • 4
  • S. R. Naidu
    • 5
  • M. A. Ferguson
    • 6
  • E. Garcia-Leavitt
    • 7
  • J. Amaro
    • 7
  • K. R. Breitenbach
    • 8
  • J. M. Watson
    • 4
    • 9
  • R. K. Gurgel
    • 5
    • 10
  • Jeffrey S. Anderson
    • 1
    • 2
    • 11
    • 13
  • N. L. Foster
    • 7
    • 12
  1. 1.Interdepartmental Program in NeuroscienceUniversity of UtahSalt Lake CityUSA
  2. 2.Department of Radiology and Imaging SciencesUniversity of UtahSalt Lake CityUSA
  3. 3.Jewish Family Services of UtahSalt Lake CityUSA
  4. 4.Department of PsychologyUniversity of UtahSalt Lake CityUSA
  5. 5.Department of Communication Sciences and DisordersUniversity of UtahSalt Lake CityUSA
  6. 6.Berenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of NeurologyHarvard Medical School and Beth Israel Deaconess Medical CenterBostonUSA
  7. 7.Center for Alzheimer Care, Imaging, and ResearchUniversity of UtahSalt Lake CityUSA
  8. 8.Genetic Science Learning CenterUniversity of UtahSalt Lake CityUSA
  9. 9.Department of PsychologyUniversity of Colorado DenverDenverUSA
  10. 10.Department of OtolaryngologyUniversity of UtahSalt Lake CityUSA
  11. 11.Department of BioengineeringUniversity of UtahSalt Lake CityUSA
  12. 12.Department of NeurologyUniversity of UtahSalt Lake CityUSA
  13. 13.1A71 School of MedicineSalt Lake CityUSA

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