The Relationship Between Physical Frailty and Mild Cognitive Impairment in the Elderly: A Systematic Review
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Physical frailty (PF) appears to be associated with low cognitive performance and mild cognitive impairment (MCI). This review evaluated and synthesized the evidence of studies investigating the association between PF and MCI, the prevalence of both conditions and the rate of conversion of healthy older adult to one of them during the follow-up.
A systematic review was performed according to the PRISMA recommendations in the Pubmed, SciELO and LILACS databases. Five studies were eligible according to inclusion and exclusion criteria.
Regarding the study design, cross-sectional studies prevailed. Most studies showed a positive association between PF and MCI. Moreover, PF seems to predict a worse cognitive trajectory among participants with MCI and it is associated to a higher risk of developing MCI.
Our findings suggest a significant association between PF and MCI. Further longitudinal studies are needed to better explore causality.
Key wordsFrailty mild cognitive impairment systematic review
Funding: Prof. Aprahamian receives National public grant level 2 from the National Council for Scientific and Technological Development (Ministry of Science, Technology, Innovation and Communications, Brazil).
Ethical standard: We agree with standards of expected ethical behavior for all parties involved in the act of publishing: the Authors, the Editor-in-Chief, the Peer-Reviewers and the Publisher. The research was conducted in accordance with the Helsinki Declaration, and the institutional review body explicitly approved the doubtful aspects of the study.
- 20.Solfrizzi V, Scafato E, Lozupone M, et al. Italian Longitudinal Study on Aging Working Group. Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging. Am J Geriatr Psychiatry. 2017;25(11):1236–1248.CrossRefGoogle Scholar
- 22.Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–9.CrossRefGoogle Scholar