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The Relationship Between Physical Frailty and Mild Cognitive Impairment in the Elderly: A Systematic Review

  • Marcus Kiiti BorgesEmail author
  • N. Oiring de Castro Cezar
  • A. Silva Santos Siqueira
  • M. Yassuda
  • M. Cesari
  • I. Aprahamian
Review
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Abstract

Introduction

Physical frailty (PF) appears to be associated with low cognitive performance and mild cognitive impairment (MCI). This review evaluated and synthesized the evidence of studies investigating the association between PF and MCI, the prevalence of both conditions and the rate of conversion of healthy older adult to one of them during the follow-up.

Methods

A systematic review was performed according to the PRISMA recommendations in the Pubmed, SciELO and LILACS databases. Five studies were eligible according to inclusion and exclusion criteria.

Results

Regarding the study design, cross-sectional studies prevailed. Most studies showed a positive association between PF and MCI. Moreover, PF seems to predict a worse cognitive trajectory among participants with MCI and it is associated to a higher risk of developing MCI.

Conclusion

Our findings suggest a significant association between PF and MCI. Further longitudinal studies are needed to better explore causality.

Key words

Frailty mild cognitive impairment systematic review 

Notes

Funding: Prof. Aprahamian receives National public grant level 2 from the National Council for Scientific and Technological Development (Ministry of Science, Technology, Innovation and Communications, Brazil).

Ethical standard: We agree with standards of expected ethical behavior for all parties involved in the act of publishing: the Authors, the Editor-in-Chief, the Peer-Reviewers and the Publisher. The research was conducted in accordance with the Helsinki Declaration, and the institutional review body explicitly approved the doubtful aspects of the study.

References

  1. 1.
    Ruiz M, Cefalu C, Reske T. Frailty syndrome in geriatric medicine. Am J Med Sci. 2012; 344:395–398.CrossRefGoogle Scholar
  2. 2.
    Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. The Scientific World. 2001;1:323–336.CrossRefGoogle Scholar
  3. 3.
    Fried LP, Tangen CM, Walston J, et al.: Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:146–156.CrossRefGoogle Scholar
  4. 4.
    Ensrud KE, Ewing SK, Taylor BC, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med. 2008; 168:382–389.CrossRefGoogle Scholar
  5. 5.
    Robertson DA, Savva GM, Kenny RA. Frailty and cognitive impairment — a review of the evidence and causal mechanisms Ageing Res Rev. 2013;12:840–851.CrossRefGoogle Scholar
  6. 6.
    Song X, Mitnitski A, Rockwood K. Age-related deficit accumulation and the risk of late-life dementia. Alzheimers Res Ther. 2014;6:54.CrossRefGoogle Scholar
  7. 7.
    Han ES, Lee Y, Kim J. Association of cognitive impairment with frailty in community-dwelling older adults. Int Psychogeriatr. 2014;26:155–163.CrossRefGoogle Scholar
  8. 8.
    Ávila-Funes JA, Amieva H, Barberger-Gateau P, et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the Three-City Study. J Am Geriatr Soc. 2009;57:453–461.CrossRefGoogle Scholar
  9. 9.
    Jacobs JM, Cohen A, Ein-Mor E, et al. Frailty, cognitive impairment and mortality among the oldest old. J Nutr Health Aging. 2011;15:678–682.CrossRefGoogle Scholar
  10. 10.
    Doi T, Shimada H, Makizako H, et al. Mild Cognitive Impairment, Slow Gait, and Risk of Disability: A Prospective Study. J Am Med Dir Assoc. 2015;16:1082–1086.CrossRefGoogle Scholar
  11. 11.
    Macuco CR, Batistoni SS, Lopes A, et al. Mini-Mental State Examination performance in frail, prefrail, and nonfrail community dwelling older adults in Ermelino Matarazzo, São Paulo, Brazil. Int Psychogeriatr. 2012;24:1725–1731.CrossRefGoogle Scholar
  12. 12.
    Montero-Odasso MM, Barnes B, Speechley M, et al. Disentangling cognitive-frailty: Results from the Gait and Brain Study. J Gerontol A Bio Sci Med Sci. 2016;71:1476–82.CrossRefGoogle Scholar
  13. 13.
    Chong MS, Tay L, Chan M, et al. Prospective longitudinal study of frailty transitions in a community-dwelling cohort of older adults with cognitive impairment. BMC Geriatr. 2015;15:175.CrossRefGoogle Scholar
  14. 14.
    Bergman H, Ferrucci L, Guralnik J, et al. Frailty: an emerging research and clinical paradigm — issues and controversies. J Gerontol A Biol Sci Med Sci. 2007;62:731–737.CrossRefGoogle Scholar
  15. 15.
    Ní Mhaoláin AM, Fan CW, Romero-Ortuno R, et al. Frailty, depression, and anxiety in later life. Int Psychogeriatr. 2012;24:1265–1274.CrossRefGoogle Scholar
  16. 16.
    Boyle PA, Buchman AS, Wilson RS, et al. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc. 2010;58:248–255.CrossRefGoogle Scholar
  17. 17.
    McGough EL, Cochrane BB, Pike KC, et al. Dimensions of physical frailty and cognitive function in older adults with amnestic mil cognitive impairment. Ann Phys Reabil Med. 2013; 56:329–341.CrossRefGoogle Scholar
  18. 18.
    Chhetri JK, Chan P, Vellas B, et al. Motoric Cognitive Risk Syndrome: predictor of dementia and age-related negative outcomes. Front Med. 2017;4:166.CrossRefGoogle Scholar
  19. 19.
    Kelaiditi E, Cesari M, Canevelli M, et al. Cognitive frailty: rational and definition from an (I.A.N.A./I.A.G.G.) international consensus group. J Nutr Health Aging. 2013;17(9):726–34.CrossRefGoogle Scholar
  20. 20.
    Solfrizzi V, Scafato E, Lozupone M, et al. Italian Longitudinal Study on Aging Working Group. Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging. Am J Geriatr Psychiatry. 2017;25(11):1236–1248.CrossRefGoogle Scholar
  21. 21.
    Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol. 1999;56(3):303–8.CrossRefGoogle Scholar
  22. 22.
    Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–9.CrossRefGoogle Scholar
  23. 23.
    Woods NF, LaCroix AZ, Gray SL, et al. Frailty: Emergence and consequences in women aged 65 and older in the Women’s Health Initiative Observational Study. J Am Geriatr Soc 2005;53:1321–30.CrossRefGoogle Scholar
  24. 24.
    Shimada H, Makizako H, Doi T, et al. Combined prevalence of failty and mild cognitive impairment in a population of elderly Japanese people. J Am Med Dir Assoc. 2013;14:518–524.CrossRefGoogle Scholar
  25. 25.
    Ní Mhaoláin AM, Gallagher D, Crosby L, et al. Correlates of frailty in Alzheimer’s disease and mild cognitive impairment. Age Ageing. 2011;40(5):630–633.CrossRefGoogle Scholar
  26. 26.
    Ruan Q, Yu Z, Chen M, et al. Cognitive frailty, a novel target for the prevention of elderly dependency. Ageing Res Rev. 2015;20:1–10.CrossRefGoogle Scholar
  27. 27.
    Solfrizzi V, Scafato E, Seripa D, et al.; Italian Longitudinal Study on Aging Working Group. Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging. J Am Med Dir Assoc. 2017;18:89.e1–89.e8.CrossRefGoogle Scholar
  28. 28.
    Buchman AS, Boyle PA, Wilson RS, et al. Frailty is associated with incident Alzheimer’s disease and cognitive decline in the elderly. Psychosom Med. 2007;69:483–489.CrossRefGoogle Scholar
  29. 29.
    Verghese J, Wang C, Lipton RB, et al. Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):412–8.CrossRefGoogle Scholar

Copyright information

© Serdi and Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marcus Kiiti Borges
    • 1
    • 6
    Email author
  • N. Oiring de Castro Cezar
    • 2
  • A. Silva Santos Siqueira
    • 1
  • M. Yassuda
    • 3
  • M. Cesari
    • 4
  • I. Aprahamian
    • 5
  1. 1.Department and Institute of Psychiatry, Faculty of MedicineUniversity of São PauloSão PauloBrazil
  2. 2.Universidade Federal de Sao Carlos Centro de Ciencias Biologicas e da SaudeSão CarlosBrazil
  3. 3.Universidade de São Paulo, Escola de Artes, Ciências e HumanidadesSão PauloBrazil
  4. 4.Fondazione IRCCS Ca’ Granda Ospedadale Maggiore PoliclinicoUniversity of MilanMilanItaly
  5. 5.Geriatrics & Psychiatry division, Department of Internal MedicineFaculty of Medicine of JundiaíJundiaíBrazil
  6. 6.Universidade de Sao Paulo Faculdade de Medicina, São PauloSão PauloBrazil

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