Advertisement

Neuroinformatics

, Volume 2, Issue 2, pp 163–168 | Cite as

Fair localization of function via multi-lesion analysis

  • Alon Keinan
  • Alon Kaufman
  • Nadia Sachs
  • Claus C. Hilgetag
  • Eytan Ruppin
Original Article

Abstract

Acknowledging that causal localization of function in a processing network requires a multi-lesion analysis, this paper presents a rigorous and efficient method for defining and calculating the functional contributions of networ elements as well as their interactions. The method’s applicability to biological networks is demonstrated in the investigation of spatial attention in cats via lesion and reversible deactivation experiments.

Index Entries

Localization of function multi-lesions Shapley value contributions analysis interactions multi-perturbations 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aharonov, R., Segev, L., Meilijson, I., and Ruppin, E. (2003) Localization of function via lesion analysis. Neural Comput. 15 (4), 885–913.CrossRefGoogle Scholar
  2. Hilgetag, C., Theoret, H., and Pascual-Leone, A. (2001) Enhanced visual spatial attention ipsilateral to rTMS-induced virtual lesions of human parietal cortex. Nat. Neurosci. 4(9), 953–957.CrossRefGoogle Scholar
  3. Hilgetag, C. C., Lomber, S. G., and Payne, B. R. (2000) Neural mechanisms of spatial attention in the cat. Neurocomputing 38, 1281–1287.CrossRefGoogle Scholar
  4. Keinan, A., Sandbank, B., Hilgetag, C. C., Meilijson, I., and Ruppin, E. (2004) Fair attribution of functional contribution in artificial and biological networks. Neural Computation 16(2).Google Scholar
  5. Lomber, S. G. and Payne, B. R. (1996) Removal of two halves restores the whole: Reversal of visual hemineglect during bilateral cortical or collicular inactivation in the cat. Vis. Neurosci. 13 (6), 1143–1156.CrossRefGoogle Scholar
  6. Lomber, S. G., Payne, B. R., and Cornwell, P. (2001) Role of the superior colliculus in analyses of space: Superficial and intermediate layer contributions to visual orienting, auditory orienting, and visuospatial discriminations during unilateral and bilateral deactivations. J. Comp. Neurol. 441, 44–57.CrossRefGoogle Scholar
  7. Lomber, S. G., Payne, B. R., Hilgetag, C. C., and Rushmore, R. J. (2002) Restoration of visual orienting into a cortically blind hemifield by reversible deactivation of posterior parietal cortex or the superior colliculus. Exp. Brain. Res. 142, 463–474.CrossRefGoogle Scholar
  8. Shapley, L. S. (1953) A value for n-person games. In: Contributions to the theory of games, volume II. (Kuhn, H. W., Tucker, A. W., eds.) Princeton University Press, Princeton, NJ, pp. 307–317.Google Scholar
  9. Sprague, J. M. (1966) Interaction of cortex and Superior Colliculus in mediation of visually guided behavior in the cat. Science 153, 1544–1547.CrossRefGoogle Scholar

Copyright information

© Humana Press Inc 2004

Authors and Affiliations

  • Alon Keinan
    • 1
  • Alon Kaufman
    • 2
  • Nadia Sachs
    • 3
  • Claus C. Hilgetag
    • 3
  • Eytan Ruppin
    • 1
    • 4
  1. 1.School of Computer ScienceTel Aviv UniversityTel AvivIsrael
  2. 2.Center of Neural ComputationHebrew UniversityJerusalemIsrael
  3. 3.School of Engineering and ScienceInternational University BremenBremenGermany
  4. 4.School of MedicineTel Aviv UniversityTel AvivIsrael

Personalised recommendations