Neurocritical Care

, Volume 2, Issue 2, pp 183–184 | Cite as

Oral clopidogrel load in aspirin-resistant capsular warning syndrome

  • Christopher D. Fahey
  • Mark J. Alberts
  • Richard A. Bernstein
Practical Pearls


Introduction: Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation.

Methods: Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel.

Results: Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction.

Conclusion: High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.

Key Words

Ischemic stroke antiplatelet therapy transient ischemic attack acute brain ischemia Capsular warning syndrome 


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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Christopher D. Fahey
    • 1
  • Mark J. Alberts
    • 1
  • Richard A. Bernstein
    • 1
  1. 1.Stroke Program, Ken and Ruth Davee Department of Neurology and Clinical Neurological SciencesFeinberg School of Medicine of Northwestern UniversityChicago

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