Medical Oncology

, Volume 18, Issue 4, pp 277–283 | Cite as

Successful treatment of gastrointestinal follicular lymphoma with rituxan and combination chemotherapy

  • Jameela Al-Salman
  • Hyamen Salib
  • Pricha Boonswang
Case Report

Abstract

The clinical course of follicular lymphoma (FL) is well known. Although it is a chemosensitive disease, thereby allowing substantial palliation, recurrence is the rule; only a small subset who presents with limited stage disease is cured. Multiple attempts have been made over the past two decades to improve the survival of patients with FL, and a large number of phase III trials have been reported. These have included a variety of different therapeutic interventions, such as combination chemotherapy, recombinant interferons, new cytotoxic drugs, and immunologic agents. Most studies have not demonstrated that the use of a particular therapy convincingly prolongs survival. Follicular lymphoma cells express CD20 and are associated in most cases with the t(14:18) chromosomal translocation. Rituximab is a chimeric monoclonal antibody directed against the B-cell CD20 antigen, which has been utilized for the therapy of B-cell non-Hodgkin’s lymphoma. Rituximab was shown to be active in FL, and studies of its effectiveness in combination with cytotoxic chemotherapy to increase the response rate are forthcoming.

Key Words

Follicular lymphoma rituximab gastrointestinal 

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Copyright information

© Humana Press Inc 2001

Authors and Affiliations

  • Jameela Al-Salman
    • 2
    • 1
  • Hyamen Salib
    • 2
    • 1
  • Pricha Boonswang
    • 2
    • 1
  1. 1.MCP-Hahnemann UniversityPhiladelphia
  2. 2.Easton HospitalEaston

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