Molecular Neurobiology

, Volume 31, Issue 1–3, pp 149–167 | Cite as

Poly(ADP-ribose) polymerase

The nuclear target in signal transduction and its role in brain ischemia-reperfusion injury
  • Robert Piotr Strosznajder
  • Henryk Jesko
  • Agata Zambrzycka


Poly(ADP-ribose) polymerase (PARP)-1 is a DNA nick sensor that transforms ADP-ribose from βNAD+ in the form of polymer to over 40 nuclear proteins, particularly to histones, several transcription factors, and PARP itself, modulating their activities and functions. PARP-1 activated by DNA breaks facilitates transcription, replication, and DNA base excision repair. The last studies indicate that PARP-1 is the new nuclear target for fast signals evoked in cell membranes by depolarization and cholinergic and glutaminergic receptors stimulation. Excessive activation of PARP-1 by peroxynitrate-evoked DNA damage during oxidative stress can cause cell death by NAD+/ATP depletion after ischemia-reperfusion injury, inflammation, and diabetes mellitus. The PARP-1 through interaction with nuclear factor-κB, p53, and other transcription factors might significantly modulate cell survival and death and a type of death pathway. The pharmacological modulation of PARP-1 might offer a new effective approach for neuroprotection.

Index Entries

PARP PARP-1 brain ischemia reperfusion NF-κB p53 neuroprotection 


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Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  • Robert Piotr Strosznajder
    • 1
  • Henryk Jesko
    • 2
  • Agata Zambrzycka
    • 2
  1. 1.Department of NeurophysiologyPolish Academy of SciencesWarsawPoland
  2. 2.Department of Cellular Signaling, Medical Research CentrePolish Academy of SciencesWarsawPoland

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