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Molecular Neurobiology

, Volume 30, Issue 2, pp 127–141 | Cite as

The physiological role of kainate receptors in the amygdala

  • Maria F. M. Braga
  • Vassiliki Aroniadou-Anderjaska
  • He Li
Article

Abstract

The kainate subtype of glutamate receptors has received considerable attention in recent years, and a wealth of knowledge has been obtained regarding the function of these receptors. Kainate receptors have been shown to mediate synaptic transmission in some brain regions, modulate presynaptic release of glutamate and γ-aminobutyric acid (GABA), and mediate synaptic plasticity or the development of seizure activity. This article focuses on the function of kainate receptors in the amygdala, a brain region that plays a central role in emotional behavior and certain psychiatric illnesses. Evidence is reviewed indicating that postsynaptic kainate receptors containing the glutamate receptor 5 kainate receptor (GLUk5) subunit are present on interneurons and pyramidal cells in the basolateral amygdala and mediate a component of the synaptic responses of these neurons to glutamatergic input. In addition, GLUk5-containing kainate receptors are present on presynaptic terminals of GABAergic neurons, where they modulate the release of GABA in an agonist concentration-dependent, bidirectional manner. GLUk5-containing kainate receptors also mediate a longlasting synaptic facilitation induced by low-frequency stimulation in the external capsule to the basolateral nucleus pathway, and they appear to be party responsible for the susceptibility of the amygdala to epileptogenesis. Taken together, these findings have suggested a prominent role of GLUk5-containing kainate receptors in the regulation of neuronal excitability in the amygdala.

Index Entries

Kainate receptors GLUk5 amygdala excitatory synaptic transmission inhibitory synaptic transmission synaptic plasticity long-term potentiation epilepsy emotional memory mood disorders 

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Copyright information

© Humana Press Inc 2004

Authors and Affiliations

  • Maria F. M. Braga
    • 1
  • Vassiliki Aroniadou-Anderjaska
    • 1
  • He Li
    • 1
  1. 1.Department of PsychiatryUniformed Services University of the Health SciencesBethesda

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