Molecular Neurobiology

, Volume 25, Issue 2, pp 113–132 | Cite as

Calcium and retinal function

  • Abram Akopian
  • Paul Witkovsky


We survey the primary roles of calcium in retinal function, including photoreceptor transduction, transmitter release by different classes of retinal neuron, calcium-mediated regulation of gap-junctional conductance, activation of certain voltage-gated channels for K+ and C1, and modulation of postsynaptic potentials in retinal ganglion cells. We discuss three mechanisms for changing [Ca2+]i, which include flux through voltage-gated calcium channels, through ligand-gated channels, and by release from stores. The neuromodulatory pathways affecting each of these routes of entry are considered. The many neuromodulatory mechanisms in which calcium is a player are described and their effects upon retinal function discussed.

Index Entries

Calcium retina phototransduction ganglion cell calmodulin glutamate metabotropic glutamate receptor GABA 


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Copyright information

© Humana Press Inc 2002

Authors and Affiliations

  1. 1.Department of Ophthalmology, New York University School of MedicineNew York University Medical CenterNew York
  2. 2.Department of Physiology & Neuroscience, New York University School of MedicineNew York University Medical CenterNew York

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