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Environmental toxins and α-synuclein in Parkinson’s disease

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Abstract

In recent years, environmental influences have been thought to play an important role in Parkinson’s disease (PD). Evidence from epidemiological investigations suggests that environmental factors might take part in the disease process. Intriguingly, most of environmental toxins share the common mechanism of causing mitochondria dysfunction by inhibiting complex I and promoting α-synuclein aggregation, a key factor in PD. Therefore, understanding the mechanism of interactions between α-synuclein and environmental factors could lead to new therapeutic approaches to PD.

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  1. Beijing Institute for Neuroscience, Capital University of Medical Science, Beijing Center of Neural Regeneration and Repairing, Beijing, China

    Yanying Liu & Hui Yang

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Liu, Y., Yang, H. Environmental toxins and α-synuclein in Parkinson’s disease. Mol Neurobiol 31, 273–282 (2005). https://doi.org/10.1385/MN:31:1-3:273

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