Molecular Biotechnology

, Volume 17, Issue 1, pp 83–89 | Cite as

Genotyping methodologies

  • S. Bevan
  • R. S. Houlston
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Abstract

With current advances in genetics it is now possible to routinely screen the entire genome of multiple affected individuals in the search for disease predisposition genes. Such a large-scale undertaking requires some careful management of both samples and data in order to make best use of all available information. Here we have detailed the two main approaches to a genome-wide search and the best ways we have found of storing, transforming, and analyzing the subsequently produced data, as well as some general considerations to enhance the chances of success.

Index Entries

Genome-wide search linkage genotyping 

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Copyright information

© Humana Press Inc 2001

Authors and Affiliations

  • S. Bevan
    • 1
  • R. S. Houlston
    • 1
  1. 1.Haddow LaboratoriesInstitute of Cancer ResearchSuttonUK

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