Journal of Molecular Neuroscience

, Volume 30, Issue 1–2, pp 65–66 | Cite as

Altered glycosylation of acetylcholinesterase in the Creutzfeldt-Jakob cerebrospinal fluid

  • Maria-Ximena Silveyra
  • Maria-Salud García-Ayllón
  • Miguel Calero
  • Javier Sáez-Valero
Original Article

Keywords

AChE Activity Molecular Neuroscience Volume Altered Glycosylation Glycosylation Machinery Sucrose Density Gradient Ultracentrifugation 

References

  1. Méflah K., Bernard S., and Massoulié J. (1984) Interactions with lectins indicate differences in the carbohydrate composition of the membrane-bound enzymes acetylcholinesterase and 5′-nucleotidase in different cell types. Biochimie 66, 59–69.PubMedCrossRefGoogle Scholar
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  3. Rudd P. M., Endo T., Colominas C., Groth D., Wheeler S. F., Harvey D. J., et al. (1999) Glycosylation differences between the normal and pathogenic prion protein isoforms. Proc. Natl. Acad. Sci. U. S. A. 96, 13,044–13,049.CrossRefGoogle Scholar
  4. Sáez-Valero J., Sberna G., McLean C. A., and Small D. H. (1999) Molecular isoform distribution and glycosylation of acetylcholinesterase are altered in brain and cerebrospinal fluid of patiens with Alzheimer's disease. J. Neurochem. 72, 1600–1608.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Maria-Ximena Silveyra
    • 1
  • Maria-Salud García-Ayllón
    • 1
  • Miguel Calero
    • 2
  • Javier Sáez-Valero
    • 1
  1. 1.Instituto de Neurociencias de AlicanteUniversidad Miguel Hernández-CSICSan Juan de AlicanteSpain
  2. 2.Unidad de Encefalopatías EspongiformesCentro Nacional de Microbiología, Instituto de Salud Carlos IIIMadridSpain

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