Journal of Molecular Neuroscience

, Volume 30, Issue 1–2, pp 145–147 | Cite as

Bioscavenger for protection from toxicity of organosphosphorus compounds

  • Ashima Saxena
  • Wei Sun
  • Chunyuan Luo
  • Todd M. Myers
  • Irwin Koplovitz
  • David E. Lenz
  • Bhupendra P. Doctor
Original Article

Keywords

Molecular Neuroscience Volume Mean Residence Time Soman Nerve Agent BChE Activity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ashani Y. (2000) Prospective of human butyryl-cholinesterase as a detoxifying antidote and potential regulator of controlled-release drugs. Drug Dev. Res. 50, 298–308.CrossRefGoogle Scholar
  2. Doctor B. P. and Saxena A. (2005) Bioscavengers for the protection of humans against organophosphate toxicity. Chem. Biol. Interact. 157–158, 167–171.PubMedCrossRefGoogle Scholar
  3. Dunn M. A. and Sidell F. R. (1989) Progress in medical defense against nerve agents. J. Am. Med. Assoc. 262, 649–652.CrossRefGoogle Scholar
  4. Gray A. P. (1984) Design and structure-activity relationships of antidotes to organophosphorus anticholinesterase agents. Drug Metab. Rev. 15, 557–589.PubMedGoogle Scholar
  5. Luo C., Bansal R., Doctor B. P., and Saxena A. (2002) Large scale purification of human serum butyrylcholinesterase. Proc. Med. Def. Biosci. Rev. 1, 319–326.Google Scholar
  6. Myers T. M., Sun W., Bansal W. R., Clark M. G., Saxena A., and Doctor B. P. (2003) Safety evaluation of human serum butyrylcholinesterase in Rhesus monkeys. Proc. Joint Service Sci. Conf. Chem. Biol. Def. Res. 1, 1–8.Google Scholar

Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Ashima Saxena
    • 1
  • Wei Sun
    • 1
  • Chunyuan Luo
    • 1
  • Todd M. Myers
    • 2
  • Irwin Koplovitz
    • 2
  • David E. Lenz
    • 2
  • Bhupendra P. Doctor
    • 1
  1. 1.Walter Reed Army Institute of ResearchSilver Spring
  2. 2.US Army Medical Research Institute of Chemical Defense, APG

Personalised recommendations