Journal of Molecular Neuroscience

, Volume 28, Issue 1, pp 53–64 | Cite as

Motoneuron injury and repair

New perspectives on gonadal steroids as neurotherapeutics
  • Julie E. Tetzlaff
  • Christopher B. Huppenbauer
  • Lisa Tanzer
  • Thomas D. Alexander
  • Kathryn J. Jones
Original Article

Abstract

In this review, we will summarize recent work from our laboratory on the role of gonadal steroids as neuroprotective agents in motoneuron viability following cell stress. Three motoneuron models will be discussed: developing axotomized hamster facial motoneurons (FMNs); adult axotomized mouse FMNs; and immortalized, cultured mouse spinal motoneurons subjected to heat shock. New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritinor candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. The concept of gonadal steroids as cellular stress correction factors and the implications of this for acute neurological injury situations will be presented as well.

Index Entries

Testosterone estrogen facial motoneurons mouse hamster immortalized mouse spinal motoneurons 

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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Julie E. Tetzlaff
    • 1
  • Christopher B. Huppenbauer
    • 1
  • Lisa Tanzer
    • 1
  • Thomas D. Alexander
    • 1
  • Kathryn J. Jones
    • 1
  1. 1.Department of Cell Biology, Neurobiology, and AnatomyLoyola University of Chicago Stritch School of MedicineMaywood

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