Motoneuron injury and repair
- 64 Downloads
In this review, we will summarize recent work from our laboratory on the role of gonadal steroids as neuroprotective agents in motoneuron viability following cell stress. Three motoneuron models will be discussed: developing axotomized hamster facial motoneurons (FMNs); adult axotomized mouse FMNs; and immortalized, cultured mouse spinal motoneurons subjected to heat shock. New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritinor candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. The concept of gonadal steroids as cellular stress correction factors and the implications of this for acute neurological injury situations will be presented as well.
Index EntriesTestosterone estrogen facial motoneurons mouse hamster immortalized mouse spinal motoneurons
Unable to display preview. Download preview PDF.
- Dhandapani K. M., Hadman M., De Sevilla L., Wade M. F., Mahesh V. B., and Brann D. W. (2003) Astrocyte protection of neurons: role of transforming growth factorbeta signaling via a c-Jun-AP-1 protective pathway. J. Biol. Chem. 278, 43,329–43,339.Google Scholar
- Jones K. J. (1999) Steroid hormones and neurotrophisms: relationship to nerve injury. Metab. Brain Dis. 3, 1–18.Google Scholar
- LaBella V., Cisterni C., Salaun D., and Pettmann B. (1998) Survival motor neuron (SMN) protein in rat is expressed as different molecular forms and is developmentally regulated. Eur. J. Neurosci. 10, 2913–2923.Google Scholar
- La Velle A. and La Velle F., eds. (1984) Neuronal Reaction to Injury During Development, Academic Press, New York.Google Scholar
- Ribotta M. G., Menet V., and Privat A. (2004) Glial scar and axonal regeneration in the CNS: lessons from GFAP and vimentin transgenic mice. Acta Neurochir. Suppl. 89, 87–92.Google Scholar
- Rossoll W., Kroning A. K., Ohndorf U. M., Steegborn C., Jablonka S., and Sendtner M. (2002) Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons? Hum. Mol. Genet. 11, 93–105.PubMedGoogle Scholar
- Tetzlaff J. E., Tanzer L. and Jones K. J. (2005a) Mechanisms of gonadal steroid-induced neuroprotection. Part I: Androgenic and estrogenic effects on mouse facial motoneuron survival and functional recovery following facial nerve injury, in review.Google Scholar
- Tetzlaff J. E., Tanzer L. and Jones K. J. (2005b) Mechanisms of gonadal steroid-induced neuroprotection. Part II: Androgenic and estrogenic effects on facial motoneuron survival following heat shock in vitro, in review.Google Scholar