Journal of Molecular Neuroscience

, Volume 25, Issue 1, pp 1–6 | Cite as

No go for brain tumors?

Short Review

Abstract

The Nogo gene and its products are well known as adult central nervous system (CNS) myelin inhibitors of neuronal regeneration. We review here experimental findings that might link Nogo to CNS malignancy. These links are founded on two very different modes of cellular action by Nogo isoforms. Acting intracellularly and in conjunction with other molecules, cytoplasmic domains of Nogo might predispose cancer cells to apoptotic susceptibility. On the other hand, extracellular domains of Nogo might inhibit the migration and invasion of CNS tumors. Depending on the physiological context, Nogo isoforms might therefore be antitumorigenic or have tumor-suppressing activities.

Index Entries

CNS malignancy glioma Nogo Nogo-66 receptor (NgR) tumor suppressor 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Acevedo L., Yu J., Erdjument-Bromage H., Miao R. Q., Kim J. E., Fulton D., et al. (2004) A new role for Nogo as a regulator of vascular remodeling. Nat. Med. 10, 382–388.PubMedCrossRefGoogle Scholar
  2. Amberger V. R., Hensel T., Ogata N., and Schwab M. E. (1998) Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity. Cancer Res. 58, 149–158.PubMedGoogle Scholar
  3. Belien A. T., Paganetti P. A., and Schwab M. E. (1999) Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter. J. Cell Biol. 144, 373–384.PubMedCrossRefGoogle Scholar
  4. Caroni P. and Schwab M. E. (1988) Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1, 85–96.PubMedCrossRefGoogle Scholar
  5. Chen M. S., Huber A. B., Van der Haar M. E. Frank M., Schnell L., Spillmann A. A., et al. (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434–439.PubMedCrossRefGoogle Scholar
  6. Domeniconi M., Cao Z., Spencer T., Sivasankaran R., Wang K., Nikulina E., et al. (2002) Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 35, 283–290.PubMedCrossRefGoogle Scholar
  7. Dupuis L., Gonzalez de Aguilar J. L., Di Scala F., Rene F., De Tapia M., et al. (2002) Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. Neurobiol. Dis. 10, 358–365.PubMedCrossRefGoogle Scholar
  8. Fournier A. E., GrandPre T., and Strittmatter S. M. (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341–346.PubMedCrossRefGoogle Scholar
  9. GrandPre T., Nakamura F., Vartanian T., and Strittmatter S. M. (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439–444.PubMedCrossRefGoogle Scholar
  10. Guerin C., Olivi A., Weingart J D., Lawson H C., and Brem H. (2004) Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. Invest. New Drugs 22, 27–37.PubMedCrossRefGoogle Scholar
  11. Hensel T., Amberger V. R., and Schwab M. E. (1998) A metalloprotease activity from C6 glioma cells inactivates the myelin-associated neurite growth inhibitors and can be neutralized by antibodies. Br. J. Cancer 78, 1564–1572.PubMedGoogle Scholar
  12. Huber A. B., Weinmann O., Brosamle C., Oertle T., and Schwab M. E. (2002) Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions. J. Neurosci. 22, 3553–3567.PubMedGoogle Scholar
  13. Hunt D., Coffin R. S., Prinjha R. K., Campbell G., and Anderson P. N. (2003) Nogo-A expression in the intact and injured nervous system. Mol. Cell Neurosci. 24, 1083–1102.PubMedCrossRefGoogle Scholar
  14. Kim J. E., Li S., GrandPre T., Qiu D., and Strittmatter S. M. (2003) Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 38, 187–199.PubMedCrossRefGoogle Scholar
  15. Li Q., Qi B., Oka K., Shimakage M., Yoshioka N., Inoue H., Hakura A., et al. (2001) Link of a new type of apoptosis-inducing gene ASY/Nogo-B to human cancer. Oncogene 20, 3929–3936.PubMedCrossRefGoogle Scholar
  16. Liao H., Duka T., Teng F. Y. H., Sun L, Bu W., Sohail A., et al. (2004) Nogo-66 and myelin-associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells. J. Neurochem. 90, 1156–1162.PubMedCrossRefGoogle Scholar
  17. Liu H., Ng C. E. L., and Tang B. L. (2002) Nogo-A expression in mouse central nervous system neurons. Neurosci. Lett. 328, 257–260.PubMedCrossRefGoogle Scholar
  18. Mi S., Lee X., Shao Z., Thill G., Ji B., Relton J., Levesque M., et al. (2004) LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat. Neurosci. 7, 221–228.PubMedCrossRefGoogle Scholar
  19. Niederost B., Oertle T., Fritsche J., McKinney R. A., and Bandtlow C. E. (2002) Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J. Neurosci. 22, 10,368–10,376.Google Scholar
  20. Ng C. E. L. and Tang B. L. (2002) Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. J. Neurosci. Res. 67, 559–565.PubMedCrossRefGoogle Scholar
  21. Oertle T., Merkler D. and Schwab M. E. (2003a) Do cancer cells die because of Nogo-B? Oncogene 22, 1390–1399.PubMedCrossRefGoogle Scholar
  22. Oertle T., Van der Haar M. E., Bandtlow C. E., Robeva A., Burfeind P., Buss A., et al. (2003b) Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions. J. Neurosci. 23, 5393–5406.PubMedGoogle Scholar
  23. Prinjha R., Moore S. E., Vinson M., Blake S., Morrow R., Christie G., et al. (2000) Inhibitor of neurite outgrowth in humans. Nature 403, 383,384.PubMedCrossRefGoogle Scholar
  24. Simonen M., Pedersen V., Weinmann O., Schnell L., Buss A., Ledermann B., et al. (2003) Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38, 201–211.PubMedCrossRefGoogle Scholar
  25. Tagami S., Eguchi Y., Kinoshita M., Takeda M., and Tsujimoto Y. (2000) A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. Oncogene 19, 5736–5746.PubMedCrossRefGoogle Scholar
  26. Tambe Y., Isono T., Haraguchi S., Yoshioka-Yamashita A., Yutsudo M., and Inoue H. (2004) A novel apoptotic pathway induced by the drs tumor suppressor gene. Oncogene 23, 2977–2987.PubMedCrossRefGoogle Scholar
  27. Wang K. C., Kim J. A., Sivasankaran R., Segal R., and He Z. (2002a) p75 interacts with the Nogo receptor as a coreceptor for Nogo, MAG and OMgp. Nature 420, 74–78.PubMedCrossRefGoogle Scholar
  28. Wang K. C., Koprivica V, Kim J. A., Sivasankaran R., Guo Y., Neve R. L., and He Z. (2002b) Oligodendrocytemyelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941–944.PubMedCrossRefGoogle Scholar
  29. Wang X., Chun S. J., Treloar H., Vartanian T., Greer C. A., and Strittmatter S. M. (2002) Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J. Neurosci. 22(13), 5505–5515.PubMedGoogle Scholar
  30. Watari A. and Yutsudo M. (2003) Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration. Apoptosis 8, 5–9.PubMedCrossRefGoogle Scholar
  31. Wong S. T., Henley J. R., Kanning K. C., Huang M., Bothwell M., and Poo M. M. (2002) A p75 (NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat. Neurosci. 5, 1302–1308.PubMedCrossRefGoogle Scholar
  32. Zheng B, Ho C., Li S., Keirstead H., Steward O., and Tessier-Lavigne M. (2003) Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38, 213–224.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  1. 1.Department of Biochemistry and Programme in Neurobiology and AgingNational University of SingaporeSingaporeRepublic of Singapore

Personalised recommendations