Journal of Molecular Neuroscience

, Volume 20, Issue 2, pp 203–206 | Cite as

The relationship between amyloid and tau

Brief Communication


Based on genetic findings, the relationship between the APP/Aβ and tau/tangle pathologies are discussed. It is argued that APP/Aβ is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Aβ can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.

Index Entries

Amyloid plaques tangles tau, genetic Alzheimer’s disease Pick’s disease 


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Copyright information

© Humana Press Inc 2003

Authors and Affiliations

  1. 1.Laboratory of NeurogeneticsNIA/NIHBethesdaUSA

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