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Journal of Molecular Neuroscience

, Volume 14, Issue 3, pp 191–196 | Cite as

Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage

  • Hyung-Min Kim
  • Hye-Young Shin
  • Hyun-Ja Jeong
  • Hyo-Jin An
  • Nam-Song Kim
  • Han-Jung Chae
  • Hyung-Ryong Kim
  • Ho-Joon Song
  • Kyung-Yo Kim
  • Seung-Hwa Baek
  • Kwang-Ho Cho
  • Byung-Soon Moon
  • Young-Mi Lee
Article

Abstract

Cytokines in the central nervous system (CNS) may play an important role in functioning as intercellular signals that orchestrate the response to injury. Whether this is a cause or result of the brain disease process is uncertain. We investigated IFN-γ, IL-2, IL-4, IL-6, and IgE in the sera of 38 patients with cerebral infarction during the acute stage and 10 normal controls using an originally devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA). We found that serum levels of IL-2 derived from T helper 1 (Th1) cells were slightly reduced in patients with cerebral infarction, whereas serum levels of IL-4 and IL-6 derived from Th2 cells were elevated significantly. IL-4 induces synthesis of IgE in human B cells. Endogenous IL-6 plays an obligatory role in IL-4-dependent human IgE synthesis. We observed that serum IgE levels were elevated significantly in patients with cerebral infarction. However, serum IFN-γ levels were not elevated significantly in cerebral infarction patients. These findings suggest that elevated IL-4, IL-6, and IgE levels in the human serum may be an important factor in cerebral infarction during the acute stage. Decrease of IL-2 levels in the serum of patients with cerebral infarction may be a regulatory mechanism.

Index Entries

IFN-γ IL-2 IL-4 IL-6 IgE cerebral infarction 

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Copyright information

© Humana Press Inc 2000

Authors and Affiliations

  • Hyung-Min Kim
    • 1
  • Hye-Young Shin
    • 1
  • Hyun-Ja Jeong
    • 1
  • Hyo-Jin An
    • 1
  • Nam-Song Kim
    • 2
  • Han-Jung Chae
    • 3
  • Hyung-Ryong Kim
    • 3
  • Ho-Joon Song
    • 4
  • Kyung-Yo Kim
    • 4
  • Seung-Hwa Baek
    • 5
  • Kwang-Ho Cho
    • 5
  • Byung-Soon Moon
    • 5
  • Young-Mi Lee
    • 1
  1. 1.Department of Oriental PharmacyCollege of Pharmacy, Center of Oriental Medicinal ScienceSouth Korea
  2. 2.Wonkwang University School of MedicineSouth Korea
  3. 3.Department of Dental PharmacologySchool of DentistrySouth Korea
  4. 4.College of Oriental MedicineSouth Korea
  5. 5.Professional Graduate School of Oriental MedicineWonkwang UniversityIksan-city, ChonbukSouth Korea

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