Skip to main content
SpringerLink
Log in

No go for brain tumors?

  • Short Review
  • Published:
Journal of Molecular Neuroscience Aims and scope Submit manuscript

Abstract

The Nogo gene and its products are well known as adult central nervous system (CNS) myelin inhibitors of neuronal regeneration. We review here experimental findings that might link Nogo to CNS malignancy. These links are founded on two very different modes of cellular action by Nogo isoforms. Acting intracellularly and in conjunction with other molecules, cytoplasmic domains of Nogo might predispose cancer cells to apoptotic susceptibility. On the other hand, extracellular domains of Nogo might inhibit the migration and invasion of CNS tumors. Depending on the physiological context, Nogo isoforms might therefore be antitumorigenic or have tumor-suppressing activities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Acevedo L., Yu J., Erdjument-Bromage H., Miao R. Q., Kim J. E., Fulton D., et al. (2004) A new role for Nogo as a regulator of vascular remodeling. Nat. Med. 10, 382–388.

    Article  PubMed  CAS  Google Scholar 

  • Amberger V. R., Hensel T., Ogata N., and Schwab M. E. (1998) Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity. Cancer Res. 58, 149–158.

    PubMed  CAS  Google Scholar 

  • Belien A. T., Paganetti P. A., and Schwab M. E. (1999) Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter. J. Cell Biol. 144, 373–384.

    Article  PubMed  CAS  Google Scholar 

  • Caroni P. and Schwab M. E. (1988) Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1, 85–96.

    Article  PubMed  CAS  Google Scholar 

  • Chen M. S., Huber A. B., Van der Haar M. E. Frank M., Schnell L., Spillmann A. A., et al. (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434–439.

    Article  PubMed  CAS  Google Scholar 

  • Domeniconi M., Cao Z., Spencer T., Sivasankaran R., Wang K., Nikulina E., et al. (2002) Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 35, 283–290.

    Article  PubMed  CAS  Google Scholar 

  • Dupuis L., Gonzalez de Aguilar J. L., Di Scala F., Rene F., De Tapia M., et al. (2002) Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. Neurobiol. Dis. 10, 358–365.

    Article  PubMed  CAS  Google Scholar 

  • Fournier A. E., GrandPre T., and Strittmatter S. M. (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341–346.

    Article  PubMed  CAS  Google Scholar 

  • GrandPre T., Nakamura F., Vartanian T., and Strittmatter S. M. (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439–444.

    Article  PubMed  CAS  Google Scholar 

  • Guerin C., Olivi A., Weingart J D., Lawson H C., and Brem H. (2004) Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. Invest. New Drugs 22, 27–37.

    Article  PubMed  CAS  Google Scholar 

  • Hensel T., Amberger V. R., and Schwab M. E. (1998) A metalloprotease activity from C6 glioma cells inactivates the myelin-associated neurite growth inhibitors and can be neutralized by antibodies. Br. J. Cancer 78, 1564–1572.

    PubMed  CAS  Google Scholar 

  • Huber A. B., Weinmann O., Brosamle C., Oertle T., and Schwab M. E. (2002) Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions. J. Neurosci. 22, 3553–3567.

    PubMed  CAS  Google Scholar 

  • Hunt D., Coffin R. S., Prinjha R. K., Campbell G., and Anderson P. N. (2003) Nogo-A expression in the intact and injured nervous system. Mol. Cell Neurosci. 24, 1083–1102.

    Article  PubMed  CAS  Google Scholar 

  • Kim J. E., Li S., GrandPre T., Qiu D., and Strittmatter S. M. (2003) Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 38, 187–199.

    Article  PubMed  CAS  Google Scholar 

  • Li Q., Qi B., Oka K., Shimakage M., Yoshioka N., Inoue H., Hakura A., et al. (2001) Link of a new type of apoptosis-inducing gene ASY/Nogo-B to human cancer. Oncogene 20, 3929–3936.

    Article  PubMed  CAS  Google Scholar 

  • Liao H., Duka T., Teng F. Y. H., Sun L, Bu W., Sohail A., et al. (2004) Nogo-66 and myelin-associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells. J. Neurochem. 90, 1156–1162.

    Article  PubMed  CAS  Google Scholar 

  • Liu H., Ng C. E. L., and Tang B. L. (2002) Nogo-A expression in mouse central nervous system neurons. Neurosci. Lett. 328, 257–260.

    Article  PubMed  CAS  Google Scholar 

  • Mi S., Lee X., Shao Z., Thill G., Ji B., Relton J., Levesque M., et al. (2004) LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat. Neurosci. 7, 221–228.

    Article  PubMed  CAS  Google Scholar 

  • Niederost B., Oertle T., Fritsche J., McKinney R. A., and Bandtlow C. E. (2002) Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J. Neurosci. 22, 10,368–10,376.

    CAS  Google Scholar 

  • Ng C. E. L. and Tang B. L. (2002) Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. J. Neurosci. Res. 67, 559–565.

    Article  PubMed  CAS  Google Scholar 

  • Oertle T., Merkler D. and Schwab M. E. (2003a) Do cancer cells die because of Nogo-B? Oncogene 22, 1390–1399.

    Article  PubMed  CAS  Google Scholar 

  • Oertle T., Van der Haar M. E., Bandtlow C. E., Robeva A., Burfeind P., Buss A., et al. (2003b) Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions. J. Neurosci. 23, 5393–5406.

    PubMed  CAS  Google Scholar 

  • Prinjha R., Moore S. E., Vinson M., Blake S., Morrow R., Christie G., et al. (2000) Inhibitor of neurite outgrowth in humans. Nature 403, 383,384.

    Article  PubMed  CAS  Google Scholar 

  • Simonen M., Pedersen V., Weinmann O., Schnell L., Buss A., Ledermann B., et al. (2003) Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38, 201–211.

    Article  PubMed  CAS  Google Scholar 

  • Tagami S., Eguchi Y., Kinoshita M., Takeda M., and Tsujimoto Y. (2000) A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. Oncogene 19, 5736–5746.

    Article  PubMed  CAS  Google Scholar 

  • Tambe Y., Isono T., Haraguchi S., Yoshioka-Yamashita A., Yutsudo M., and Inoue H. (2004) A novel apoptotic pathway induced by the drs tumor suppressor gene. Oncogene 23, 2977–2987.

    Article  PubMed  CAS  Google Scholar 

  • Wang K. C., Kim J. A., Sivasankaran R., Segal R., and He Z. (2002a) p75 interacts with the Nogo receptor as a coreceptor for Nogo, MAG and OMgp. Nature 420, 74–78.

    Article  PubMed  CAS  Google Scholar 

  • Wang K. C., Koprivica V, Kim J. A., Sivasankaran R., Guo Y., Neve R. L., and He Z. (2002b) Oligodendrocytemyelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941–944.

    Article  PubMed  CAS  Google Scholar 

  • Wang X., Chun S. J., Treloar H., Vartanian T., Greer C. A., and Strittmatter S. M. (2002) Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J. Neurosci. 22(13), 5505–5515.

    PubMed  CAS  Google Scholar 

  • Watari A. and Yutsudo M. (2003) Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration. Apoptosis 8, 5–9.

    Article  PubMed  CAS  Google Scholar 

  • Wong S. T., Henley J. R., Kanning K. C., Huang M., Bothwell M., and Poo M. M. (2002) A p75 (NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat. Neurosci. 5, 1302–1308.

    Article  PubMed  CAS  Google Scholar 

  • Zheng B, Ho C., Li S., Keirstead H., Steward O., and Tessier-Lavigne M. (2003) Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38, 213–224.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, 117597, Singapore, Republic of Singapore

    Felicia Yu Hsuan Teng & Bor Luen Tang

Authors
  1. Felicia Yu Hsuan Teng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bor Luen Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bor Luen Tang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hsuan Teng, F.Y., Luen Tang, B. No go for brain tumors?. J Mol Neurosci 25, 1–6 (2005). https://doi.org/10.1385/JMN:25:1:001

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/JMN:25:1:001

Index Entries

Search

Navigation