Immunologic Research

, Volume 36, Issue 1–3, pp 51–60 | Cite as

Dissecting the humoral immune response to simian immunodeficiency virus

Mechanisms of antibody-mediated virus neutralization
  • Jonathan D. Steckbeck
  • Kelly Stefano Cole


The ultimate goal of an AIDS vaccine is to elicit potent cellular and humoral immune responses that will result in broadly enduring protective immunity. During the past several years, we have focused on characterizing the quantitative and qualitative properties of the antibody response, principally working to define the mechanism(s) of antibody-mediated neutralization in vitro. We have utilized a panel of monoclonal antibodies generated from monkeys infected with attenuated SIV for more than 8 mo to dissect the early events of virus infection involved in antibody-mediated neutralization. Presented herein are highlights from our studies that have identified potential mechanisms by which antibodies neutralize SIV in vitro.

Key Words

Neutralization Antibody Surface plasmon resonance SIV envelope Vaccine 


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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  1. 1.Department of Medicine, Infections Diseases DivisionUniversity of Pittsburgh School of MedicinePittsburgh

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