Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles
- 437 Downloads
Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.
Key WordsExosomes Microvesicles Human tumors Dendritic cells T cells Apoptosis
Unable to display preview. Download preview PDF.
- 1.Taylor DD, Black PH: Neoplastic and developmental importance of plasma membrane vesicles. Am Zool 1987;26:411–415.Google Scholar
- 2.Taylor DD, Black PH: Shedding of plasma membrane fragments. Neoplastic and developmental importance. Dev Biol 1986;3:33–57.Google Scholar