Immunologic Research

, Volume 36, Issue 1–3, pp 147–155 | Cite as

Immune regulation by the TIM gene family

  • Anjali J. de Souza
  • Lawrence P. Kane


Recent studies have demonstrated that proteins of the T cell immunologobulin and mucin domain (TIM) family are important regulators of immune function. Here we discuss the functional effects of TIM proteins on immune responses, how the effects of TIM proteins may be modulated by interactions with ligands and the limited information available on intracellular signals downstream of TIM proteins.

Key Words

T cells Activation Asthma Autoimmunity Co-stimulation Mucins 


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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Anjali J. de Souza
    • 1
  • Lawrence P. Kane
    • 1
  1. 1.Department of ImmunologyUniversity of Pittsburgh School of MedicinePittsburgh

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