Immunologic Research

, Volume 30, Issue 3, pp 309–325 | Cite as

Manipulating the type 1 vs type 2 balance in type 1 diabetes

  • Urs Christen
  • Mathias G. von Herrath
Article

Abstract

Virus infections cause a strong inflammatory reaction that is dominated by the expression of type 1 cytokines and chemokines. Such an aggressive immune response by the host is necessary to eliminate intracellular pathogens. However, because of this shift in the type 1 vs type 2 balance of the immune response, virus infections are potential candidates for triggering autoimmune diseases, such as type 1 diabetes (T1D), herpes stromal keratitis, or multiple sclerosis (MS). In this review we will focus on the pathogenesis of T1D in a virus-induced transgenic mouse model and discuss possibilities of how an aggressive type 1-dominated immune response can be restrained and autoimmunity be abrogated.

Key Words

Chemokines cytokines CXCL10 TNFα LCMV autoimmunity inflammation 

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Copyright information

© Humana Press Inc 2004

Authors and Affiliations

  • Urs Christen
    • 1
  • Mathias G. von Herrath
    • 1
  1. 1.Dept of Developmental ImmunologyLa Jolla Institute for Allergy and ImmunologySan Diego

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