Immunologic Research

, Volume 26, Issue 1–3, pp 289–296 | Cite as

Islet transplantation in the twenty-first century

  • Frank T. Thomas
  • Anne Hutchings
  • Juan Contreras
  • Jianguo Wu
  • Xiao Ling Jiang
  • Devin Eckhoff
  • Judith M. Thomas
Article

Abstract

Isolated islet transplantation is poised for clinical application to treat insulin-dependent diabetes. Unlike exogenous insulin therapy, islet transplantation has promise for preventing and/or reversing the dismal secondary complications of diabetes. Islet transplants are arguably the most unique type of allografts, and we discuss their properties, limitations, and potential in this overview. The induction of immunologic tolerance to allow islet grafts to endure and prevail, without the hardship of chronic immunosuppressive therapy, is a major goal in this field. In this context, we discussour successful results in preclinical models of primate allogeneic and xenogeneic islet graft tolerance.

Key words

Animal Diabetes Immunotoxin Islets Pancreas Primate Transplantation Xenotransplantation 

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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Frank T. Thomas
    • 1
  • Anne Hutchings
    • 1
  • Juan Contreras
    • 1
  • Jianguo Wu
    • 1
  • Xiao Ling Jiang
    • 1
  • Devin Eckhoff
    • 1
  • Judith M. Thomas
    • 1
  1. 1.Transplantation Immunobiology, Department of SurgeryUniversity of Alabama at BirminghamBirmingham

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