Immunologic Research

, Volume 26, Issue 1–3, pp 191–197 | Cite as

Mast cell regulation via paired immunoglobulin-like receptor PIR-B

  • Ching-Cheng Chen
  • Dong-Won Kang
  • Max D. Cooper
  • Hiromi Kubagawa
Article

Abstract

Activating (PIR-A) and inhibitory (PIR-B) isoforms of the paired immunoglobulin (Ig)-like receptor family have been evaluated for their modulating potential in mast cell responses to IgE antibody and mast/stem cell growth factor (SCF). Mast cells produce PIR-A and PIR-B, but PIR-B was found to be predominantly expressed on the cell surface, where it wasconstitutively tyrosine phosphorylated and associated with SHP-1 tyrosine phosphatase. Efficient coligation of PIR-B with FceRI inhibited IgE-induced mast cell activation and seroton in release. PIR-B and c-kit (or mast/SCF receptor) coligation also inhibited SCF-induced mast cell responses. The PIR-B inhibitory activity was unimpaired in SHP-1-deficient mast cells, perhaps because of non-SHP-1-binding tyrosine-based inhibitory motif in the cytoplasmic tail of PIR-B. This analysis suggests that PIR-B may serve to control mast cell activity.

Key Words

Mast cells/basophils Immunoreceptor tyrosine-based inhibitory motif Protein tyrosine phosphatase SHP-1 Paired immunoglobulin-like receptors Inhibitory immune receptors 

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Copyright information

© Humana Press Inc. 2002

Authors and Affiliations

  • Ching-Cheng Chen
    • 1
  • Dong-Won Kang
    • 2
  • Max D. Cooper
    • 3
  • Hiromi Kubagawa
    • 2
  1. 1.Division of Developmental and clinical Immunology, Department of MicrobiologyUniversity of Alabama at BirminghamBirmingham
  2. 2.Department of PathologyUniversity of Alabama at BirminghamBirmingham
  3. 3.Department of MedicineHoward Hughes Medical InstituteBirmingham

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