Immunologic Research

, Volume 24, Issue 3, pp 303–310 | Cite as

Double light chain producing lymphocytes

An enigma of allellc exclusion
Article

Abstract

The infrequent double light chain producing lymphocyte (DLCPL) is discussed in the context of allelic exclusion. Principally allelic selection rather than allelic exclusion would suggest a role for the DLCPL in the normal B cell population rather than as an aberrance of B cell malignancy. Found primarily in the periphery, it is uncertain at what stage of B cell ontogeny the DLCPL might reside. Nevertheless, through the possible presentation of two functional surface receptors, the DLCPL could be capable of recognizing both self and nonself epitopes.

Key Words

B lymphocyte Double light chain Allelic exclusion Kappa Lambda 

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Copyright information

© Humana Press Inc 2001

Authors and Affiliations

  1. 1.Laboratory of Genetics National Cancer InstituteNIHBethesda

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