Immunologic Research

, Volume 23, Issue 1, pp 41–58 | Cite as

IL-6-like cytokines and cancer cachexia

Consequences of chronic inflammation
  • Beverly E. Barton
Article

Abstract

An estimated 30% of cancer deaths are attributed to cachexia and its consequences. Cachexia (wasting syndrome) is the hypercatabolism of the body's carbon sources, proteins and lipids, for conversion into energy. It is induced by a variety of pathological conditions, including cancer. Among the inflammatory responses to cancer is the synthesis of cytokines, including IL-6 and related cytokines. These cytokines have been found to induce cach exia by altering metabolism of lipids and proteins. IL-6-like cytokines have been found to inhibit lipid biosynthesis by adipocytes, which increased the rate of lipid catabolism. Others have described the atrophy and increased catabolism of muscle protein due to IL-6. A cytokine closely-related to IL-6 is leptin, which plays a major role in lipid metabolism under normal conditions. The role of leptin in pathological conditions such as cancer cachexia has not yet been fully elucidated. Detailed mechanistic information about the induction of cancer cachexia by IL-6-like cytokines requires more research.

Key Words

Cancer Cachexia IL-6 IL-11 Oncostatin M Leptin 

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Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  • Beverly E. Barton
    • 1
  1. 1.Department of SurgeryUniversity of Medicine & Dentistry of New Jersey New Jersey Medical SchoolNewark

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