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International Journal of Pancreatology

, Volume 25, Issue 1, pp 17–21 | Cite as

Molecular forms of serum pancreatic stone protein in acute pancreatitis

  • Yasuyuki Nakae
  • Satoru Naruse
  • Motoji Kitagawa
  • Hiroshi Ishiguro
  • Masanori Kato
  • Shinobu Hayakawa
  • Takaharu Kondo
  • Tetsuo Hayakawa
Article

Summary

Conclusion: Elevation of serum pancreatic stone protein- (PSP) S1 suggests activation of trypsinogen in the pancreas. This information would prompt the start of intensive treatment and may improve prognosis of acute pancreatitis (AP).

Background: PSP exists in two molecular forms, PSP-S2–5 and PSP-S1. PSP-S1 is produced by enzyme cleavage of PSP-S2–5 by trypsin. Total serum PSP rose in AP, but little is known about its molecular forms. In this study, we characterized the molecular forms of serum PSP in AP.

Methods: Sera were taken from 8 patients with severe acute pancreatitis (sAP) and from 11 patients with mild acute pancreatitis (mAP). Serum PSP was characterized by high-performance liquid chromatography (HPLC) followed by the specific enzyme immunoassay (EIA).

Results: The total serum PSP in sAP was higher than in mAP, but the difference was not significant. The PSP-S1 was detected in serum in all (7/7) patients in sAP and in 72% (8/11) of patients in mAP. Serum level of PSP-S1 was significantly higher in sAP than that in mAP (p<0.05), and the cutoff value to distinguish the two groups was 30 ng/mL. Serum PSP-S1 did not show significant correlation with total PSP, immunoreactive trypsin, or C-reactive protein.

Key Words

Pancreatic stone protein acute pancreatitis trypsin molecular form 

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Copyright information

© Humana Press Inc 1999

Authors and Affiliations

  • Yasuyuki Nakae
    • 1
  • Satoru Naruse
    • 1
  • Motoji Kitagawa
    • 1
  • Hiroshi Ishiguro
    • 1
  • Masanori Kato
    • 2
  • Shinobu Hayakawa
    • 2
  • Takaharu Kondo
    • 1
  • Tetsuo Hayakawa
    • 1
  1. 1.Second Department of Internal MedicineNagoya University School of MedicineNagoyaJapan
  2. 2.Department of Clinical ChemistryMaruko Pharmaceutical Co., Ltd.KasugaiJapan

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