Endocrine Pathology

, Volume 17, Issue 3, pp 283–290 | Cite as

Lymphocytic insulitis in a juvenile dog with diabetes mellitus

  • G. Jouvion
  • J. Abadie
  • J. M. Bach
  • F. Roux
  • J. Miclard
  • J. Y. Deschamps
  • L. Guigand
  • P. Saï
  • M. Wyers
Animal Model


Autoimmune diabetes has never been described in a juvenile dog, whereas serologica evidence has established its development in adult dogs. Diabetes mellitus was diagnosea in a 3-mo-old Donge de Bordeaux dog suffering from persistent hyperglycemia and concurrent insulinopenia. Histological analysis of the pancreas revealed in flammatory lesions in 40% of the islets of Lagerhans, with infiltration predominantly by T lymphocytes (more than 90%), either at the edge (peri-insulitis: 10%) or in the islets (insulitis: 30%). The remaining 60% of the islets showed a marked atrophy due to massive beta cell loss with no loss of alpha cells. This pattern is quite similar to that observed in humans in which a characteristic insulitis containing high numbers of T lymphocytes is found in 20% of the islets at diabetes diagnosis. By contrast, in rodent models, nearly 70% of the islets of langerhans show inflamation at diagnosis and macrophages and dendritic cells predominate in the inflamatory lesions. This is the first report of lymphocytic insulitis in a juvenile dog exhibiting diabetes mellitus. Our observations suggest an autoimmune origin for the disease in this dog that is similar to human type 1 diabetes mellitus, for which there is no accurate spontaneous large animal model.

Key words

Autoimmune disease diabetes mellitus dog juvenile onset lymphocytic insulitis 


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Copyright information

© Humana Press Inc 2006

Authors and Affiliations

  • G. Jouvion
    • 1
  • J. Abadie
    • 1
  • J. M. Bach
    • 2
  • F. Roux
    • 2
    • 3
  • J. Miclard
    • 1
  • J. Y. Deschamps
    • 2
    • 3
  • L. Guigand
    • 1
  • P. Saï
    • 2
  • M. Wyers
    • 1
  1. 1.UMR 703 INRA-ENVN, Department of PathologyNational Veterinary School of NautesFrance
  2. 2.IECM Unit, INRA U707University, National Veterinary School of NantesFrance
  3. 3.Eniergency and Critical Care UnitNational Veterinary School of NantesFrance

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