Endocrine Pathology

, Volume 16, Issue 1, pp 83–89 | Cite as

Warthin tumor-like variant of papillary thyroid carcinoma: A case with dedifferentiation (anaplastic changes) and aggressive biological behavior

  • King Yin Lam
  • Chung Yau Lo
  • William I. Wei
Case Report


Warthin tumor-like variant of papillary thyroid carcinoma is uncommon and approx 80 cases have been reported in the literature. This tumor is often associated with a favorable prognosis. In this report, a Warthin tumor-like variant of the papillary thyroid carcinoma, 5-cm in maximum dimension, underwent anaplastic changes in a 74-yr-old woman. The tumor was positive for CD15 and EMA, and a high proliferative index was noted in the anaplastic area. The patient developed distant metastases after operation and died of the disease 18 mo after the operation. The present case is the first reported case of Warthin tumor-like variant of papillary thyroid carcinoma with anaplastic changes.

Key Words

Papillary thyroid carcinoma Warthin tumor-like variant undifferentiated carcinoma anaplastic carcinoma 


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Copyright information

© Humana Press Inc 2005

Authors and Affiliations

  1. 1.Discipline of Pathology, School of MedicineGriffith UniversityGold CoastAustralia
  2. 2.Department of Surgery, Faculty of MedicineUniversity of Hong KongHong Kong

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