Comparison of fine-needle-nonaspiration with fine-needle-aspiration technique in the cytologic studies of thyroid nodules
Introduction: Fine needle aspiration (FNA) has been adopted as a simple and cost effective technique for cytologic studies of thyroid nodules. The recently introduced fine needle nonaspiration (FNNA) technique, however, is claimed to be superior because it provides specimens with larger number of cells and better preserved cytomorphology and architecture of thyroid papillae and follicles. In this study, we compare the efficacy of the two methods.
Materials and Methods: Two hundred patients with thyroid nodules, 1–4 cm in size, were recruited. FNA and FNNA techniques were applied to each patient. In a single-blind setting, all specimens were examined by a single cytopathologist. The specimens were scored (0, 1, or 2) on the basis of background blood or clot, number of obtained cells, preserved architecture of papillae and follicles, and cellular degeneration. Nonparameteric methods were then used to compare the scores of the two techniques.
Results: Two hundred patients (162 female, 38 male) were entered into the study. Specimens from 43 patients were inadequate. In the remaining 157 patients, no statistically significant difference was seen between FNNA and FNA average scores in each parameter (p>0.05).
Conclusion: We concluded that FNNA is not superior to FNA in the cytopathologic studies of thyroid nodules.
Key WordsFine needle aspiration fine needle nonaspiration thyroid nodules cytology
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- 3.Tunbridge WM, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7:481–493, 1977.Google Scholar
- 4.Azizi F, Mirresalimi M, Azizi M. The effect of thyroxin therapy on the size of cold thyroid nodules in patients from an iodine deficient area. Med J IR Iran 6:161–165, 1992.Google Scholar
- 5.Aziz F, Kimeiagar M, Nafarabadi MT. Current statues of iodine deficiency disorders in the Islamic Republic of Iran. EMR Health Serv J 8:23–27, 1990.Google Scholar
- 8.Gharib H. Fine-needle aspiration biopsy of the thyroid nodules: advantages, limitation, and effect. Mayo Clin Prac 69:44–49, 1994.Google Scholar
- 11.Regina M, Gharib H. Thyroid fine-needle aspiration biopsy: progress, practice and pitfalls. Endocr Pract 23:564–572, 2003.Google Scholar
- 17.Dey P, Ray R. Comparison of fine needle sampling by capillary action and fine needle aspiration. Cytopathol 4:299–303, 1993.Google Scholar
- 19.Fagelman D. Nonaspiration fine needle cytology of liver. Am J Roentgenol 155:1217–1219, 1990.Google Scholar