Endocrine Pathology

, Volume 14, Issue 4, pp 369–373 | Cite as

Comparison of fine-needle-nonaspiration with fine-needle-aspiration technique in the cytologic studies of thyroid nodules

  • Shahram Haddadi-Nezhad
  • Bagher Larijani
  • Seyed Mohammad Tavangar
  • Seyed Mahdi Nouraei
Clinical Research


Introduction: Fine needle aspiration (FNA) has been adopted as a simple and cost effective technique for cytologic studies of thyroid nodules. The recently introduced fine needle nonaspiration (FNNA) technique, however, is claimed to be superior because it provides specimens with larger number of cells and better preserved cytomorphology and architecture of thyroid papillae and follicles. In this study, we compare the efficacy of the two methods.

Materials and Methods: Two hundred patients with thyroid nodules, 1–4 cm in size, were recruited. FNA and FNNA techniques were applied to each patient. In a single-blind setting, all specimens were examined by a single cytopathologist. The specimens were scored (0, 1, or 2) on the basis of background blood or clot, number of obtained cells, preserved architecture of papillae and follicles, and cellular degeneration. Nonparameteric methods were then used to compare the scores of the two techniques.

Results: Two hundred patients (162 female, 38 male) were entered into the study. Specimens from 43 patients were inadequate. In the remaining 157 patients, no statistically significant difference was seen between FNNA and FNA average scores in each parameter (p>0.05).

Conclusion: We concluded that FNNA is not superior to FNA in the cytopathologic studies of thyroid nodules.

Key Words

Fine needle aspiration fine needle nonaspiration thyroid nodules cytology 


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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Shahram Haddadi-Nezhad
    • 1
  • Bagher Larijani
    • 2
  • Seyed Mohammad Tavangar
    • 3
  • Seyed Mahdi Nouraei
    • 4
  1. 1.Endocrinologist, Endocrinology and Metabolism Research CenterTehran University of Medical SciencesTehranIran
  2. 2.Endocrinology, Endocrinology and Metabolism Research CenterTehran University of Medical SciencesTehranIran
  3. 3.Department of PathologyTehran University of Medical SciencesTehranIran
  4. 4.Endocrinology and Metabolism Research CenterTehran University of Medical SciencesTehranIran

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