Endocrine Pathology

, Volume 13, Issue 2, pp 157–165 | Cite as

Prolactin-producing pituitary adenoma associated with prolactin cell hyperplasia

  • Sergio Vidal
  • Eva Horvath
  • Luis V. Syro
  • Humberto Uribe
  • Sandy Cohen
  • Kalman Kovacs
Case Report


A 24-yr-old woman with amenorrhea, galactorrhea, hyperprolactinemia, and sellar mass underwent transsphenoidal surgery. Histologic, immunohistochemical, and electron microscopic investigation revealed a well-differentiated, sparsely granulated prolactin (PRL) cell adenoma of the pituitary showing conclusive PRL immunoreactivity. In the nontumorous adenohypophysis PRL cell hyperplasia was noted. Marked differences were evident between the neoplastic and hyperplastic areas. The tumor consisted of sparsely granulated PRL cells immunoreactive only for PRL. As demonstrated by immunoelectron microscopy, the hyperplastic are a comprised monohormonal sparsely granulated PRL cells as well as bihormonal mammosomatotrophs immunoreactive for both PRL and growth hormone. The MIB-1 index was higher whereas microvessel density was lower in the adenoma as compared with the hyperplastic area. In addition, the nontumorous area showed lymphocytic infiltration whereas inflammatory reaction was not seen in the adenoma. This case represents a rare association of a PRL cell adenoma and PRL cell hyperplasia. The fact that these two lesions were contiguous in the surgically removed material raises the possibility that hyperplasia can precede and transform into adenoma.

Key Words

Prolactin adenoma pituitary hyperplasia human electron microscopy immunohistochemistry 


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Copyright information

© Humana Press Inc 2002

Authors and Affiliations

  • Sergio Vidal
    • 1
    • 2
  • Eva Horvath
    • 1
  • Luis V. Syro
    • 3
  • Humberto Uribe
    • 4
  • Sandy Cohen
    • 1
  • Kalman Kovacs
    • 1
  1. 1.Department of Laboratory Medicine, Division of PathologySt. Michael’s HospitalTorontoCanada
  2. 2.Department of Anatomy, Laboratory of HistologyUniversity of Santiago de CompostelaLugoSpain
  3. 3.Departments of Neurosurgery Clinica MedellinHospital Pablo Tobon UribeMedellinColombia
  4. 4.Universidad de AntioquiaMedellinColombia

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