Endocrine Pathology

, Volume 12, Issue 4, pp 437–441 | Cite as

Juvenile rheumatoid arthritis with amyloid goiter: Report of a case with review of the literature

  • Amitabh Srivastava
  • Mukta Baxi
  • Subhash Yadav
  • Amit Agarwal
  • Ramesh K. Gupta
  • Saroj K. Misra
  • Ambrish Mithal
Case Report


Clinically significant enlargement of the thyroid owing to amyloid deposition is a rare occurrence. A 23-yr-old female, a case of juvenile rheumatoid arthritis, developed rapidly increasing thyromegaly during the course of her illness with complaints of dyspnea and dysphagia. Thyroid function tests were within normal limits. Fine-needle aspiration cytology proved inconclusive. Total thyroidectomy was done for symptomatic relief with a preoperative clinical impression of malignancy. Histopathologic findings were consistent with amyloid goiter. The findings of this case are presented, to emphasize the difficulties in making a definite preoperative diagnosis, along with a brief review of the literature.

Key Words

Amyloidosis thyroid goiter rheumatoid arthritis 


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Copyright information

© Humana Press Inc 2001

Authors and Affiliations

  • Amitabh Srivastava
    • 1
  • Mukta Baxi
    • 2
  • Subhash Yadav
    • 3
  • Amit Agarwal
    • 2
  • Ramesh K. Gupta
    • 1
  • Saroj K. Misra
    • 2
  • Ambrish Mithal
    • 3
  1. 1.Department of PathologySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia
  2. 2.Department of Endocrine SurgerySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia
  3. 3.Department of Medical EndocrinologySanjay Gandhi Postgraduate Institute of Medical SciencesLucknowIndia

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