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Expression of MAGE tumor-associated antigen in thyroid carcinomas

  • Clinical Research
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Abstract

The 12 members of the MAGE gene family encode tumor-specific antigens that are recognized by autologous cytotoxic T lymphocytes. The MAGE genes are expressed not only in melanoma but in other malignant tumors as well. There is, however, little information on their expression in thyroid carcinomas. We studied the expression of the MAGE-3 antigen in human thyroid carcinomas to explore the possibility of specific immunotherapy using MAGE peptides. Tumor tissue samples of thyroid carcinomas were obtained from 60 patients. Standard pathohistologic analysis followed by immunohistochemistry analysis of MAGE-3 expression was performed in all patients. The overall expression rate of MAGE-3 antigen in thyroid carcinomas was 65%. According to histological types of thyroid carcinomas, expression rate of MAGE-3 antigen was as follows: 0% in anaplastic, 20% in medullary, 29% in follicular, and 80% in papillary thyroid carcinomas (p<0.01). On the other hand, significantly higher expression of MAGE-3 antigen was observed in classical subtypes of papillary thyroid carcinomas and in small papillary tumors sized to 1 cm in diameter. These findings demonstrated that MAGE-3 antigen expression seems to be particularly high in the small, typical papillary carcinomas, thus suggesting that MAGE-3 gene abnormality is an early step in thyroid cancer progression.

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Authors and Affiliations

  1. Department of Pathology, University Hospital “Merkur”, Zajceva 19, 10000, Zagreb, Croatia

    Marija Milkovic MD

  2. Department of Pathology, University Hospital for Tumors, Ilica 197, 10 000, Zagreb, Croatia

    Bozena Sarcevic MD, PhD

  3. Department of Surgery, Clinic Hospital “Sestre milosrdnice”, Vinogradska 29, 10000, Zagreb, Croatia

    Elizabet Glavan MD

Authors
  1. Marija Milkovic MD
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  2. Bozena Sarcevic MD, PhD
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  3. Elizabet Glavan MD
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Correspondence to Elizabet Glavan MD.

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Milkovic, M., Sarcevic, B. & Glavan, E. Expression of MAGE tumor-associated antigen in thyroid carcinomas. Endocr Pathol 17, 45–52 (2006). https://doi.org/10.1385/EP:17:1:45

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