Skip to main content
Log in

A solitary minute thyroid lymphoma of MALT-type without lymphoid thyroiditis

  • Case Report
  • Published:
Endocrine Pathology Aims and scope Submit manuscript

Abstract

Most of the primary thyroid malignant lymphomas have been considered of mucosa-associated lymphoid tissue (MALT) type and arise from lymphocytic thyroiditis. We report an uncommon case of a 67-yr-old man who underwent total thyroidectomy for multinodular goiter with tracheal compression. At histopathologic examination, we discovered a minute (3-mm diameter) lesion of low-grade thyroid lymphoma of MALT type without any lymphocytic thyroiditis lesion on 33 section levels of the entire thyroid gland. No general inflammatory, autoimmune, or lymphomatous disorder has been evidenced both at staging and after 30 mo of follow-up. MALT-type low-grade lymphoma may, in some instances, develop de novo within the thyroid without an antecedent MALT-type lymphoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Anscombe AM, Wright DH. Primary malignant lymphoma of the thyroid—a tumour of mucosa-associated lymphoid tissue: review of seventy-six cases. Histopathology 9:81–97, 1985.

    Article  PubMed  CAS  Google Scholar 

  2. Hyjek E, Isaacson PG. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis. Hum Pathol 19:1315–1326, 1988.

    Article  PubMed  CAS  Google Scholar 

  3. Pedersen RK, Pedersen NT. Primary non-Hodgkin’s lymphoma of the thyroid gland: a population based study. Histopathology 28:25–32, 1996.

    Article  PubMed  CAS  Google Scholar 

  4. Skacel M, Ross CW, Hsi ED. A reassessment of primary thyroid lymphoma: high-grade MALT-type lymphoma as a distinct subtype of diffuse large B-cell lymphoma. Histopathology 37:10–18, 2000.

    Article  PubMed  CAS  Google Scholar 

  5. Isaacson P, Wright DH. Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 53:2515–2524, 1984.

    Article  PubMed  CAS  Google Scholar 

  6. Derringer GA, Thompson LD, Frommelt RA, Bijwaard KE, Heffess CS, Abbondanzo SL. Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases. Am J Surg Pathol 24:623–639, 2000.

    Article  PubMed  CAS  Google Scholar 

  7. Haciyanli M, Erkan N, Yorukoglu K, Sagol O, Harmancioglu O. Primary non-Hodgkin’s T-cell lymphoma of the thyroid gland complicating Hashimoto’s thyroiditis: case report. Thyroid 10:717–720, 2000.

    Article  PubMed  CAS  Google Scholar 

  8. Hsi ED, Singleton TP, Svoboda SM, Schnitzer B, Ross CW. Characterization of the lymphoid infiltrate in Hashimoto thyroiditis by immunohistochemistry and polymerase chain reaction for immunoglobulin heavy chain gene rearrangement. Am J Clin Pathol 110:327–333, 1998.

    PubMed  CAS  Google Scholar 

  9. Bateman AC, Wright DH. Epitheliotropism in high-grade lymphomas of mucosa-associated lymphoid tissue. Histopathology 23:409–415, 1993.

    Article  PubMed  CAS  Google Scholar 

  10. Apel RL, Asa SL, Chalvardjian A, LiVolsi VA. Intrathyroidal lymphoepithelial cysts of probable branchial origin. Hum Pathol 25:1238–1242, 1994.

    Article  PubMed  CAS  Google Scholar 

  11. Thieblemont C, Bastion Y, Berger F, Rieux C, Salles G, Dumontet C, Felman P, Coiffier B. Mucosa-associated lymphoid tissue gastrointestinal and nongastrointestinal lymphoma behavior: analysis of 108 patients. J Clin Oncol 15:1624–1630, 1997.

    PubMed  CAS  Google Scholar 

  12. Nakao A, Fujisawa K, Mimura H, Ezawa K, Natsumeda M, Fukuoka K, Isozaki H, Tanaka N. Mucosa-associated lymphoid tissue (MALT) lymphoma of the thyroid: report of a case. Anticancer Res 19:811–814, 1999.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hélène Trouette MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trouette, H., Dubus, P., Belleannée, G. et al. A solitary minute thyroid lymphoma of MALT-type without lymphoid thyroiditis. Endocr Pathol 13, 235–238 (2002). https://doi.org/10.1385/EP:13:3:235

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1385/EP:13:3:235

Key Words

Navigation