, Volume 29, Issue 3, pp 491–499 | Cite as

Expression of kallikrein, bradykinin B2 receptor, and endothelial nitric oxide synthase in placenta in normal gestation, preeclampsia, and placenta accreta

  • Jenny Corthorn
  • Alfredo A. Germain
  • Cecilia Chacón
  • Sergio Rey
  • Gloria X. Soto
  • Carlos D. Figueroa
  • Werner Müller-Esterl
  • Ignacio Duarte
  • Gloria Valdés
Original Articles


In an effort to define the varied expression of three vasoactive markers in the clinical models of normal placenta/normal invasion (n=11), preeclampsia/restricted trophoblast invasion (n=15), and placenta accreta/exaggerated invasion (n=6), we performed semiquantitative immunohistochemistry for kallikrein, bradykinin B2 receptor, and endothelial nitric oxide synthase (eNOS). In the floating villi, the syncytiotrophoblast expressed more kallikrein in placenta accreta (p<0.05), than in normal and preeclamptic placentas, while the bradykinin B2 receptor and eNOS were similarly expressed in all groups; in the fetal endothelium, the bradykinin B2 receptor was enhanced in placenta accreta (p<0.005), but kallikrein and eNOS were similarly expressed in the other two groups. In the extravillous trophoblast, both kallikrein and eNOS expression were higher in placenta accreta (p<0.001), while the bradykinin B2 receptor signal was only enhanced in preeclampsia (p<0.05). The presence and localization of kallikrein, the bradykinin B2 receptor, and eNOS in the fetomaternal interface in the three study conditions supports a local role for interrelated vasodilatory/antiaggregating systems. This first report of the variations observed in kallikrein and eNOS in a condition of exaggerated trophoblast invasion supports the participation of vasodilatation in trophoblast migration.

Key Words

Kallikrein bradykinin B2 receptor endothelial nitric oxide synthase normal placenta preeclampsia accreta 


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Copyright information

© Humana Press Inc. 2006

Authors and Affiliations

  • Jenny Corthorn
    • 1
  • Alfredo A. Germain
    • 3
  • Cecilia Chacón
    • 1
  • Sergio Rey
    • 1
    • 2
  • Gloria X. Soto
    • 5
  • Carlos D. Figueroa
    • 6
  • Werner Müller-Esterl
    • 7
  • Ignacio Duarte
    • 4
  • Gloria Valdés
    • 1
    • 2
  1. 1.Centro de Investigaciones MédicasPontificia Universidad Católica de ChileSantiagoChile
  2. 2.Departamento de NefrologíaPontificia Universidad Católica de ChileSantiagoChile
  3. 3.Departamento de Obstetricia/GinecologíaPontificia Universidad Católica de ChileSantiagoChile
  4. 4.Departamento de Patología, Escuela de MedicinaPontificta Universidad Católica de ChileSantiagoChile
  5. 5.Servicio Obstetricia y GinecologíaHospital Paula JaraquemadaSantiagoChile
  6. 6.Instituto Histología y PatologíaUniversidad AustralValdiviaChile
  7. 7.Institute for Biochemistry IIUniversity of Frankfurt Medical SchoolFrankfurtGermany

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