Abstract
The involvement of excitatory amino acids in the control of ACTH release is well established. Activation of ionotropic glutamate receptors has a stimulatory effect on ACTH release, while the role of metabotropic receptors is not yet understood in detail. Glutamatergic regulation of ACTH release has a clear significance for the stress response and neuroendocrine functions during development. A dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis has been reported in several psychiatric and neurological disorders. So far, only fractional indices on the clinical importance of the interaction between glutamate and ACTH secretion have been obtained in both preclinical and clinical studies. Some antidepressant drugs, such as tianeptine, which were found to modulate ACTH release, appear to interfere with brain glutamatergic system. Changes in ACTH and cortisol release may be of importance for mood stabilizing effects of antiepileptic drugs modulating glutamate release, such as lamotrigine. Brain glutamate and HPA axis interaction seems to be of importance in alcohol and drug abuse. Little information is available on ACTH release in response to glutamate-modulating drugs used in the treatment of schizophrenia and Alzheimer disease. Nevertheless, pharmacological interventions influencing interaction between glutamate and the HPA axis are promising treatment possibilities in psychiatry and neurology.
Similar content being viewed by others
References
Makara, G. B. and Stark, E. (1975). Neuroendocrinology 18, 213–216.
Gay, V. L. and Plant, T. M. (1987). Endocrinology 120, 2289–2296.
Farah, J. M. Jr., Rao, T. S., Mick, S. J., Coyne, K. E., and Iyengar, S. (1991). Endocrinology 128, 1875–1880.
Jezova, D., Oliver, C., and Jurcovicova, J. (1991). Neuroendocrinology 54, 488–492.
Yousef, K. A., Tepper, P. G., Molina, P. E., Abumrad, N. N., and Lang, C. H. (1994). Brain Res. 634, 131–140.
Pechnick, R. N., George, R., and Poland, R. E. (1989). Eur. J. Pharmacol. 164, 257–263.
Jezova, D., Tokarev, D., and Rusnak, M. (1995). Neuroendocrinology 62, 326–332.
Pechnick, R. N. and Poland, R. E. (2004). J. Pharmacol. Exp. Ther. 309, 515–522.
Tokarev, D. and Jezova, D. (1997). Methods Find. Exp. Clin. Pharmacol. 19, 323–328.
Zelena, D., Makara, G. B., and Jezova, D. (1999). Neuroendocrinology 69, 316–323.
Broadbear, J. H., Winger, G., and Woods, J. H. (2004). Psychopharmacology (Berlin) 176, 398–406.
Lang, C. H. and Ajmal, M. (1995). Am. J. Physiol. 268, R1026-R1033.
Johnson, M. P., Kelly, G., and Chamberlain, M. (2001). J. Neuroendocrinol. 13, 670–677.
Scaccianoce, S., Matrisciano, F., Del Bianco, P., et al. (2003). Neuropharmacology 44, 555–561.
Bradbury, M. J., Giracello, D. R., Chapman, D. F., et al. (2003). Neuropharmacology 44, 562–572.
Aubry, J. M., Bartanusz, V., Pagliusi, S., Schulz, P., and Kiss, J. Z. (1996). Neurosci. Lett. 205, 95–98.
Herman, J. P., Eyigor, O., Ziegler, D. R., and Jennes, L. (2000). J. Comp. Neurol. 422, 352–362.
Kocsis, K., Kiss, J., Gorcs, T., and Halasz, B. (1998). Neuroreport 9, 4029–4033.
Herman, J. P., Mueller, N. K., and Figueiredo, H. (2004). Ann. NY Acad. Sci. 1018, 35–45.
Hrabovszky, E., Wittmann, G., Turi, G. F., Liposits, Z., and Fekete, C. (2005). Endocrinology 146, 341–347.
Joanny, P., Steinberg, J., Oliver, C., and Grino, M. (1997). J. Neuroendocrinol. 9, 93–97.
Zelena, D., Mergl, Z., and Makara, G. B. (2005). Brain Res. 1031, 185–193.
Jezova, D., Vigas, M., Bartanusz, V., Reymond, M. J., and Zorad, S. (1996). In: Stress: molecular genetic and neurobiological advances. McCarty, R., Aguilera, G., Sabban, E., and Kvetnansky R. (eds.). Gordon and Breach Science Publishers: New York, pp. 417–430.
Jezova, D. and Schwendt, M. (2005). In: Glutamate receptors in peripheral tissue: excitatory transmission outside the CNS. Gill, S. and Pulido O. (eds.). Kluwer Academic/Plenum Publishers: New York, pp. 169–178.
Lowy, M. T., Gault, L., and Yamamoto, B. K. (1993). J. Neurochem. 61, 1957–1960.
Moghaddam, B. (1993). J. Neurochem. 60, 1650–1657.
Bartanusz, V., Aubry, J. M., Pagliusi, S., Jezova, D., Baffi, J., and Kiss, J. Z. (1995). Neuroscience 66, 247–252.
Fitzgerald, L. W., Ortiz, J., Hamedani, A. G., and Nestler, E. J. (1996). J. Neurosci. 16, 274–282.
Schwendt, M. and Jezova, D. (2000). Cell. Mol. Neurobiol. 20, 319–329.
Akinbami, M. A., Philip, G. H., Sridaran, R., Mahesh, V. B., and Mann, D. R. (1999). J. Steroid Biochem. Mol. Biol. 70, 143–149.
Reagan, L. P., Rosell, D. R., Wood, G. E., et al. (2004). Proc. Natl. Acad. Sci. USA 101, 2179–2184.
Boudouresque, F., Chautard, T., Jezova, D., et al. (1991). Endocr. Regul. 25, 44–52.
Skultetyova, I., Tokarev, D. I., and Jezova, D. (1993). Endocr. Regul. 27, 209–213.
Olney, J. W. (1969). Science 164, 719–721.
Skultetyova, I., Kiss, A., and Jezova, D. (1998). Neuroendocrinology 67, 412–420.
Leret, M. L., Peinado, V., Suarez, L. M., Tecedor, L., Gamallo, A., and Gonzalez, J. C. (2004). Int. J. Dev. Neurosci. 22, 87–93.
Chautard, T., Boudouresque, F., Guillaume, V., and Oliver, C. (1993). Neuroendocrinology 57, 70–78.
Kent, S., Kernahan, S. D., and Levine, S. (1996). Brain Res. Dev. Brain Res. 94, 1–13.
Jezova, D., Kiss, A., Tokarev, D., and Skultetyova, I. (1998). Stress Med. 14, 255–260.
Makatsori, A., Dubovicky, M., Ujhazy, E., Bakos, J., and Jezova, D. (2005). Neurotoxicol. Teratol. 27, 509–514.
Jezova, D., Skultetyova, I., Makatsori, A., Moncek, F., and Duncko, R. (2002). Stress 5, 177–183.
Bakos, J., Duncko, R., Makatsori, A., Pirnik, Z., Kiss, A., and Jezova, D. (2004). Ann. NY Acad. Sci. 1018, 281–287.
Kendell, S. F., Krystal, J. H., and Sanacora, G. (2005). Expert. Opin. Ther. Targets 9, 153–168.
Tichomirowa, M. A., Keck, M. E., Schneider, H. J., et al. (2005). J. Endocrinol. Invest. 28, 89–99.
Stahl, S. M. and Grady, M. M. (2003). J. Clin. Psychiatry 64 (Suppl. 13), 13–17.
Duncko, R., Schwendt, M., and Jezova, D. (2003). Pharmacol. Biochem. Behav. 76, 9–16.
Strohle, A. and Holsboer, F. (2003). Pharmacopsychiatry 36 (Suppl. 3), S207-S214.
Reid, I. C. and Stewart, C. A. (2004). Neurotox. Res. 6, 483–489.
McEwen, B. S. and Olie, J. P. (2005). Mol. Psychiatry 10, 525–537.
Delbende, C., Tranchand, B. D., Tarozzo, G., et al. (1994). Eur. J. Pharmacol. 251, 245–251.
Jezova, D. and Duncko, R. (2002). J. Psychopharmacol. 16, 235–240.
Du, J., Gray, N. A., Falke, C. A., et al. (2004). J. Neurosci. 24, 6578–6589.
Zarate, C. A. Jr., Quiroz, J. A., Singh, J. B., et al. (2005). Biol. Psychiatry 57, 430–432.
Kniest, A., Wiesenberg, C., Weber, B., Colla, M., Heuser, I., and Deuschle, M. (2001). Neuropsychobiology 43, 91–95.
Makatsori, A., Duncko, R., Moncek, F., Loder, I., Katina, S., and Jezova, D. (2004). Neuroendocrinology 79, 34–42.
Pistovcakova, J., Makatsori, A., Sulcova, A., and Jezova, D. (2005). Eur. Neuropsychopharmacol. 15, 153–158.
Tzschentke, T. M. and Schmidt, W. J. (2003). Mol. Psychiatry 8, 373–382.
Schmidt, E. D., Tilders, F. J., Janszen, A. W., Binnekade, R., De Vries, T. J., and Schoffelmeer, A. N. (1995). Eur. J. Pharmacol. 285, 317–321.
Jezova, D., Mlynarik, M., Zelena, D., and Makara, G. B. (2004). Brain Res. 1021, 63–68.
Kim, J. H., Austin, J. D., Tanabe, L., Creekmore, E., and Vezina, P. (2005). Eur. J. Neurosci. 21, 295–300.
Torres, G., Rivier, C., and Weiss, F. (1994). Brain Res. 656, 33–42.
Makatsori, A., Duncko, R., Schwendt, M., Moncek, F., Johansson, B. B., and Jezova, D. (2003). Psychoneuroendocrinology 28, 702–714.
Schwendt, M., Duncko, R., Makatsori, A., Moncek, F., Johansson, B. B., and Jezova, D. (2003). Neurochem. Res. 28, 653–657.
Nakagawa, T. and Satoh, M. (2004). Ann. NY Acad. Sci. 1025, 383–388.
Le Greves, P., Huang, W., Zhou, Q., Thornwall, M., and Nyberg, F. (1998). Eur. J. Pharmacol. 341, 161–164.
Zhu, H., Jang, C. G., Ma, T., Oh, S., Rockhold, R. W., and Ho, I. K. (1999). Eur. J. Pharmacol. 365, 47–54.
Pirnik, Z., Schwendt, M., and Jezova, D. (2001). Endocr. Regul. 35, 187–193.
Nagy, J. (2004). Drugs 7, 339–350.
Scott, L. J., Figgitt, D. P., Keam, S. J., and Waugh, J. (2005). CNS Drugs 19, 445–464.
Zimmerman, U., Spring, K., Koller, G., Holsboer, F., and Soyka, M. (2004). Pharmacopsychiatry 37, 98–102.
Elman, I., Lukas, S. E., Karlsgodt, K. H., Gasic, G. P., and Breiter, H. C. (2003). Psychopharmacol. Bull. 37, 84–89.
McCullumsmith, R. E., Clinton, S. M., and Meador-Woodruff, J. H. (2004). Int. Rev. Neurobiol. 59, 19–45.
Javitt, D. C. (2004). Mol. Psychiatry 9, 984–997.
Zhang, X. Y., Zhou, D. F., Cao, L. Y., Wu, G. Y., and Shen, H. C. (2005). Neuropsychopharmacology 30, 1532–1538.
Altamura, A. C., Boin, F., and Maes, M. (1999). Eur. Neuropsychopharmacol. 10, 1–4.
Hynd, M. R., Scott, H. L., and Dodd, P. R. (2004). Neurochem. Int. 45, 583–595.
Farlow, M. R. (2004). Geriatrics 59, 22–27.
Pascualy, M., Petrie, E. C., Brodkin, K., Peskind, E. R., Wilkinson, C. W., and Raskind, M. A. (2000). Biol. Psychiatry 48, 247–254.
Zhou, Y., Yuferov, V. P., Spangler, R., Maggos, C. E., Ho, A., and Kreek, M. J. (1998). Eur. J. Pharmacol. 352, 65–71.
Hergovich, N., Singer, E., Agneter, E., et al. (2001). Neuropsychopharmacology 24, 590–593.
Murck, H., Struttmann, T., Czisch, M., Wetter, T., Steiger, A., and Auer, D. P. (2002). Neuropsychobiology 45, 120–123.
van Berckel, B. N., Lipsch, C., Gispen-de Wied, C., et al. (1998). Psychopharmacology (Berlin) 138, 190–197.
Deuster, P. A., Faraday, M. M., Chrousos, G. P., and Poth, M. A. (2005). J. Clin. Endocrinol. Metab. 90, 4777–4783.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jezova, D. Control of ACTH secretion by excitatory amino acids. Endocr 28, 287–293 (2005). https://doi.org/10.1385/ENDO:28:3:287
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/ENDO:28:3:287