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Endocrine

, Volume 26, Issue 3, pp 227–233 | Cite as

Gonadotropin gene targeting and biological implications

  • T. Rajendra Kumar
Article

Abstract

Pituitary gonadotropins FSH and LH are heterodimeric glycoproteins consisting of a common alpha and a hormone-specific beta subunit that are non-covalently linked. These hormones orchestrate gonadal growth, differentiation, and function by regulating both steroidogenesis and gametogenesis. Advances in the past two decades in manipulating the mouse genome by site-specific mutagenesis have heralded a new dimension to our understanding of the biology of gonadotropins. Using these gene-targeting approaches, knockout mice lacking the hormone-specific gonadotropin subunits, and hence the functional dimeric hormones, have been generated. These individual gonadotropin-deficient mice are useful to delineate the distinct in vivo biological roles of FSH and LH. These mice also serve as valuable genetic tools to study the signaling mechanisms within the gonads and help a better understanding of some forms of human infertility.

Key Words

Knockout mice pituitary LH FSH hCG testis ovary 

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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineUniversity of Kansas Medical CenterKansas City
  2. 2.Department of Molecular and Integrative PhysiologyUniversity of Kansas Medical CenterKansas City

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