Advertisement

Endocrine

, Volume 22, Issue 2, pp 155–159 | Cite as

High prevalence of thyroid ultrasonographic abnormalities in primary aldosteronism

  • Decio Armanini
  • Davide Nacamulli
  • Carla Scaroni
  • Franco Lumachi
  • Riccardo Selice
  • Cristina Fiore
  • Gennaro Favia
  • Franco Mantero
Article

Abstract

The study was performed to evaluate the prevalence of thyroid abnormalities detected by ultrasonography and, in particular, of multinodular nontoxic goiter in primary aldosteronism. We analyzed 80 consecutive of patients with primary hyperaldosteronism (40 with unilateral adenoma and 40 with idiopathic hyperaldosteronism) and 80 normotensive healthy controls, comparable for age, sex, iodine intake, and geographical area. Blood pressure, thyroid palpation, thyroid function, and ultrasonography were evaluated. The prevalence of ultrasonographic thyroid abnormalities was 60% in primary aldosteronism and 27% in controls (p<0.0001). There was a statistically significant difference in prevalence of these abnormalities in unilateral adenoma and idiopathic hyperaldosteronism with respect to controls (p<0.05 and p<0.0001, respectively). The prevalence of multinodular nontoxic goiter in idiopathic hyperaldosteronism was higher than in controls (p<0.001) and, in particular, in female patients. From these data it seems to be worth considering the existence of primary hyperaldosteronism in patients with multinodular goiter and hypertension.

Key Words

Primary hyperaldosteronism thyroid abnormalities ultrasonography multinodular goiter 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Gordon, R. D. (1995). J. Endocrinol. Invest. 18, 495–511.PubMedGoogle Scholar
  2. 2.
    Bornstein, S. R., Stratakis, C. A., and Chrousos, G. P. (1999). Ann. Intern. Med. 130, 759–771.PubMedGoogle Scholar
  3. 3.
    Lifton, R. P., Dluhy, R. G., Powers, M., et al. (1992). Nature 355, 262–265.PubMedCrossRefGoogle Scholar
  4. 4.
    Rioperez, E., Botella, J. M., Valdivieso, L., Ballesteros, D., Diez, L., and Navas, J. (1981). Horm. Metab. Res. 13, 186–187.PubMedGoogle Scholar
  5. 5.
    Beckers, A., Abs, R., Willems, P. J., et al. (1992). J. Clin. Endocrinol. Metab. 75, 564–570.PubMedCrossRefGoogle Scholar
  6. 6.
    Rojeski, M. T. and Gharib, H. (1985). N. Engl. J. Med. 313, 428–436.PubMedCrossRefGoogle Scholar
  7. 7.
    Tan, G. H. and Gharib, H. (1997). Ann. Intern. Med. 126, 226–231.PubMedGoogle Scholar
  8. 8.
    Ezzat, S., Sarti, D. A., Cain, D. R., and Braunstein, G. D. (1994). Arch. Intern. Med. 154, 1838–1840.PubMedCrossRefGoogle Scholar
  9. 9.
    Tomimori, E., Pedrinola, F., Cavaliere, H., Knobel, M., and Medeiros-Neto, G. (1995). Thyroid 5, 273–276.PubMedGoogle Scholar
  10. 10.
    Brander, A., Viikinkoski, P., Nickels, J., and Kivisaari, L. (1991). Radiology 181, 683–687.PubMedGoogle Scholar
  11. 11.
    Knudsen, N., Bulow, I., Jorgensen, T., Laurberg, P., Ovesen, L., and Perrild, H. (2000). Clin. Endocrinol. (Oxf.) 53, 479–485.CrossRefGoogle Scholar
  12. 12.
    Woestyn, J., Afschrift, M., Schelstraete, K., and Vermeulen, A. (1985). Br. J. Radiol. 58, 1179–1182.PubMedGoogle Scholar
  13. 13.
    Rago, T., Chiovato, L., Aghini-Lombardi, F., Grasso, L., Pinchera, A., and Vitti, P. (2001). J. Endocrinol. Invest. 24, 770–776.PubMedGoogle Scholar
  14. 14.
    Gasperi, M., Martino, E., Manetti, L., et al. (2002). J. Endocrinol. Invest. 25, 240–245.PubMedGoogle Scholar
  15. 15.
    Schulte, K. M., Antoch, G., Ellrichmann, M., et al. (1998). Exp. Clin. Endocrinol. Diabetes 106, 310–318.PubMedCrossRefGoogle Scholar
  16. 16.
    Thompson, S. D., Franklyn, J. A., Watkinson, J. C., Verhaeg, J. M., Sheppard, M. C., and Eggo, M. C. (1998). J. Clin. Endocrinol. Metab. 83, 1336–1341.PubMedCrossRefGoogle Scholar
  17. 17.
    Bidey, S. P., Hill, D. J., and Eggo, M. C. (1999). J. Endocrinol. 160, 321–332.PubMedCrossRefGoogle Scholar
  18. 18.
    Stern, N., Greeman, J., Trostanetski, Y., et al. (2000). The Endocrine Society 82nd Annual Meeting, June 21–24, p. 309.Google Scholar
  19. 19.
    Tan, S. A. and Tan, L. G. (1990). Horm. Res. 34, 83–87.PubMedGoogle Scholar
  20. 20.
    Mantero, F., Opocher, G., Boscaro, M., Valpione, E., Armanini, D., and Fallo, F. (1981). Horm. Metab. Res. 13, 464–467.PubMedCrossRefGoogle Scholar
  21. 21.
    Fardella, C. E., Mosso, L., Gomez-Sanchez, C., et al. (2000). J. Clin. Endocrinol. Metab. 86, 1863–1867.CrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Decio Armanini
    • 1
  • Davide Nacamulli
    • 1
  • Carla Scaroni
    • 1
  • Franco Lumachi
    • 2
  • Riccardo Selice
    • 1
  • Cristina Fiore
    • 1
  • Gennaro Favia
    • 2
  • Franco Mantero
    • 1
  1. 1.Department of Medical and Surgical Sciences, EndocrinologyUniversity of PaduaItaly
  2. 2.Department of Gastroenterological and Surgical Sciences, Surgical EndocrinologyUniversity of PaduaItaly

Personalised recommendations