Endocrine

, Volume 20, Issue 3, pp 279–283 | Cite as

Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas

  • Annamaria Colao
  • Mariagiovanna Filippella
  • Carolina Di Somma
  • Simona Manzi
  • Francesca Rota
  • Rosario Pivonello
  • Maria Gaccione
  • Michele De Rosa
  • Gaetano Lombardi
Article

Abstract

Besides well-known effects in GH-secreting adenomas, somatostatin analogs such as octreotide and lanreotide have been used in TSH-secreting adenomas and in the so-called clinically nonfunctioning adenomas. The rationale for their use is based on the evidence that both these tumor types express large amounts of somatostatin receptor subtypes 2 and 5, which are preferentially bound by octreotide and lanreotide. However, whether in TSH-secreting adenomas the results are excellent in the nonfunctioning type, the results are controversial. Some preliminary results showing a very rapid recovery of the visual field have not been confirmed subsequently. No evident effect of tumor shrinkage has been reported. At present, the use of somatostatin analogs in clinically nonfunctioning adenomas is questioned.

Key Words

Pituitary adenomas somatostatin octreotide lanreotide 

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References

  1. 1.
    Guillemin, R. (1978). Science 202, 390–402.PubMedCrossRefGoogle Scholar
  2. 2.
    Guillemin, R. (1981). J. Endocrinol. 90, 3–10.Google Scholar
  3. 3.
    Lamberts, S. W., Krenning, E. P., and Reubi, J. C. (1991). Endocr. Rev. 12, 450–482.PubMedGoogle Scholar
  4. 4.
    Newman, C. B., Melmed, S., George, A., et al. (1998). J. Clin. Endocrinol. Metab. 83, 3034–3040.PubMedCrossRefGoogle Scholar
  5. 5.
    Lamberts, S. W. J., van der Lely, A.-J., de Herder, W. W., and Hofland, L. J. (1996). N. Engl. J. Med. 334, 246–254.PubMedCrossRefGoogle Scholar
  6. 6.
    Morange I, de Boisvilliers F, Chanson P, et al. (1994). J. Clin. Endocrinol. Metab. 79, 145–151.PubMedCrossRefGoogle Scholar
  7. 7.
    Giusti, M., Gussoni, G., Cuttica, C. M., Giordano, G., and the Italian Multicenter Slow Release Lanreotide Study Group. (1996). J. Clin. Endocrinol. Metab. 81, 2089–2097.PubMedCrossRefGoogle Scholar
  8. 8.
    Gillis, J. C., Noble, S., and Goa, K. L. (1997). Drugs 53, 681–699.PubMedGoogle Scholar
  9. 9.
    Colao, A., Ferone, D., Marzullo, P., et al. (2001). J. Clin. Endocrinol. Metab. 86, 2779–2786.PubMedCrossRefGoogle Scholar
  10. 10.
    Beck-Peccoz, P., Brucker-Davis, F., Persani, L., Smallridge, R. C., and Weintraub, B. D. (1996). Endocr. Rev. 17, 610–638.PubMedCrossRefGoogle Scholar
  11. 11.
    Brucker-Davis Oldfield, E. H., Skarulis, M. C., Doppman, J. L., and Weintraub, B. D. (1999). J. Clin. Endocrinol. Metab. 84, 476–486.CrossRefGoogle Scholar
  12. 12.
    Freda, P. U. and Wardlaw, S. L. (1999). J. Clin. Endocrinol. Metab. 84, 3859–3866.PubMedCrossRefGoogle Scholar
  13. 13.
    Bevan, J. S., Webster, J., Burke, C. W., and Scanlon, M. F. (1992). Endocr. Rev. 13, 221–235.CrossRefGoogle Scholar
  14. 14.
    Bertherat, J., Brue, T., Enjalbert, A., et al. (1992). J. Clin. Endocrinol. Metab. 75, 540–546.PubMedCrossRefGoogle Scholar
  15. 15.
    Losa, M., Magnani, P., Mortini, P., et al. (1997). Eur. J. Nucl. Med. 24, 728–731.PubMedGoogle Scholar
  16. 16.
    Comi, R. J., Gesunheit, N., Murray, L., Gorden, P., and Weintraub, B. D. (1987). N. Engl. J. Med. 317, 12–17.PubMedCrossRefGoogle Scholar
  17. 17.
    Chanson, P., Weintraub, B. D., and Harris, A. G. (1993). Ann. Intern. Med. 119, 236–240.PubMedGoogle Scholar
  18. 18.
    Fukuda, T., Yokoyama, N., Tamai, M., et al. (1998). Intern. Med. 37, 1027–1030.PubMedGoogle Scholar
  19. 19.
    Gancel, A., Vuillermet, P., Legrand, A., Catus, F., Thomas, F., and Kuhn, J. M. (1994). Clin. Endocrinol. 40, 421–428.CrossRefGoogle Scholar
  20. 20.
    Kuhn, J. M., Arlot, S., Lefebvre, H., et al. (2000). J. Clin. Endocrinol. Metab. 85, 1487–1491.PubMedCrossRefGoogle Scholar
  21. 21.
    Caron, P., Arlot, S., Bauters, C., et al. (2001). J. Clin. Endocrinol. Metab. 86, 2849–2853.PubMedCrossRefGoogle Scholar
  22. 22.
    Katnelson, L., Alexander, J. M., and Klibanski, A. (1993). J. Clin. Endocrinol. Metab. 76, 1089–1094.CrossRefGoogle Scholar
  23. 23.
    Ebersold, M. J., Quast, L. M., Laws, E. R., Scheitauer, B., and Randall, R. V. (1986). J. Neurosurg. 64, 713–719.PubMedCrossRefGoogle Scholar
  24. 24.
    Harris, P. E., Afshar, F., Coates, P., et al. (1989). Q. J. Med. 71, 417–427.PubMedGoogle Scholar
  25. 25.
    Colao, A., Cerbone, G., Cappabianca, P., et al. (1998). J. Endocrinol. Invest. 21, 284–290.PubMedGoogle Scholar
  26. 26.
    Littley, M. D., Shalet, S. M., Beardwell, C. G., Ahmed, S. R., Applegate, G., and Sutton, M. I. (1989). Q. J. Med. N. Series 70, 145.Google Scholar
  27. 27.
    Turner, H. E., Stratton, I. M., Byrne, J. V., Adams, C. B., and Wass, J. A. (1999). Clin. Endocrinol. 51, 281–284.CrossRefGoogle Scholar
  28. 28.
    Lamberts, S. W. J., de Herder, W. W., van der Lely, A. J., and Hofland, L. J. (1995). Endocrinologist 5, 448–451.CrossRefGoogle Scholar
  29. 29.
    Ferone, D., Lastoria, S., Colao, A., et al. (1998). J. Clin. Endocrinol. Metab. 83, 248–252.PubMedCrossRefGoogle Scholar
  30. 30.
    Colao, A., Ferone, D., Lastoria, S., et al. (2000). Clin. Endocrinol. 52, 437–445.CrossRefGoogle Scholar
  31. 31.
    Faglia, G., Bazzoni, N., Spada, A., et al. (1991). J. Clin. Endocrinol. Metab. 73, 850–856.PubMedCrossRefGoogle Scholar
  32. 32.
    Plockinger, U., Reichel, M., Fett, U., Saeger, W., and Quabbe, H. J. (1994). J. Clin. Endocrinol. Metab. 79, 1416–1423.PubMedCrossRefGoogle Scholar
  33. 33.
    Duet, M., Mundler, O., Ajzenberg, C., et al. (1994). Eur. J. Nucl. Med. 21, 647–650.PubMedCrossRefGoogle Scholar
  34. 34.
    Florio, T., Thellung, S., Arena, S., et al. (1999). Eur. J. Endocrinol. 141, 396–408.PubMedCrossRefGoogle Scholar
  35. 35.
    Colao, A., Lastoria, S., Ferone, D., et al. (1999). J. Endocrinol. Invest. 22, 176–183.PubMedGoogle Scholar
  36. 36.
    Warnet, A., Harris, A. G., Renard, E., Martin, D., James-Deidier, A., Chaumet-Riffaud, P., and the French multicenter octreotide study group. (1997). Neurosurgery 41, 786–797.PubMedCrossRefGoogle Scholar
  37. 37.
    De Bruin, T. W. A., Kwekkeboom, D. J., van’t Verlaat, J. W., et al. (1992). J. Clin. Endocrinol. Metab. 75, 1310–1317.PubMedCrossRefGoogle Scholar
  38. 38.
    van Hagen, P. M., Baarsma, G. S., Mooy, C. M., et al. (2000). Eur. J. Endocrinol. 143(Suppl. 1), S43-S51.PubMedCrossRefGoogle Scholar
  39. 39.
    Wagenaar, A. H., Harris, A. G., van der Lely, A. J., and Lamberts, S. W. (1991). Acta Endocrinol. (Copenh.) 125, 637–642.Google Scholar
  40. 40.
    Flogstad, A. K., Halse, J., Grass, P., et al. (1994). J. Clin. Endocrinol. Metab. 79, 461–465.PubMedCrossRefGoogle Scholar
  41. 41.
    Lombardi, G., Colao, A., Ferone, D., et al. (1995). Eur. J. Endocrinol. 132, 559–564.PubMedGoogle Scholar
  42. 42.
    Marzullo, P., Ferone, D., Di Somma, C., et al. (1999). Pituitary 1, 115–120.PubMedCrossRefGoogle Scholar
  43. 43.
    Rocheville, M., Lange, D. C., Kumar, U., Patel, S. C., Patel, R. C., and Patel, Y. C. (2000). Science 288, 154–157.PubMedCrossRefGoogle Scholar
  44. 44.
    Andersen, M., Bjerret, P., Schroder, H. D., et al. (2001). Clin. Endocrinol. 54, 23–30.CrossRefGoogle Scholar
  45. 45.
    Jaquet, P., Ouafik, L., Saveanu, A., et al. (1999). J. Clin. Endocrinol. Metab. 84, 3268–3276.PubMedCrossRefGoogle Scholar
  46. 46.
    Shimon, I., Yan, X., Taylor, J. E., Weiss, M. H., Culler, M. D., and Melmed, S. (1997). J. Clin. Invest. 100, 2386–2392.PubMedCrossRefGoogle Scholar
  47. 47.
    Culler, M. D., Taylor, J. E., and Moreau, J. P. (2002). Ann. Endocrinol. (Paris) 63, 2S5–12.Google Scholar
  48. 48.
    Weckbecker, G., Briner, U., Lewis, I., and Bruns, C. (2002). Endocrinology 143, 4123–4130.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Annamaria Colao
    • 1
  • Mariagiovanna Filippella
    • 1
  • Carolina Di Somma
    • 1
  • Simona Manzi
    • 1
  • Francesca Rota
    • 1
  • Rosario Pivonello
    • 1
  • Maria Gaccione
    • 1
  • Michele De Rosa
    • 1
  • Gaetano Lombardi
    • 1
  1. 1.Department of Molecular and Clinical Endocrinology and Oncology“Federico II” UniversityNaplesItaly

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