, Volume 20, Issue 3, pp 279–283 | Cite as

Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas

  • Annamaria Colao
  • Mariagiovanna Filippella
  • Carolina Di Somma
  • Simona Manzi
  • Francesca Rota
  • Rosario Pivonello
  • Maria Gaccione
  • Michele De Rosa
  • Gaetano Lombardi


Besides well-known effects in GH-secreting adenomas, somatostatin analogs such as octreotide and lanreotide have been used in TSH-secreting adenomas and in the so-called clinically nonfunctioning adenomas. The rationale for their use is based on the evidence that both these tumor types express large amounts of somatostatin receptor subtypes 2 and 5, which are preferentially bound by octreotide and lanreotide. However, whether in TSH-secreting adenomas the results are excellent in the nonfunctioning type, the results are controversial. Some preliminary results showing a very rapid recovery of the visual field have not been confirmed subsequently. No evident effect of tumor shrinkage has been reported. At present, the use of somatostatin analogs in clinically nonfunctioning adenomas is questioned.

Key Words

Pituitary adenomas somatostatin octreotide lanreotide 


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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Annamaria Colao
    • 1
  • Mariagiovanna Filippella
    • 1
  • Carolina Di Somma
    • 1
  • Simona Manzi
    • 1
  • Francesca Rota
    • 1
  • Rosario Pivonello
    • 1
  • Maria Gaccione
    • 1
  • Michele De Rosa
    • 1
  • Gaetano Lombardi
    • 1
  1. 1.Department of Molecular and Clinical Endocrinology and Oncology“Federico II” UniversityNaplesItaly

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