, Volume 13, Issue 2, pp 193–199 | Cite as

Use of sibutramine and other noradrenergic and serotonergic drugs in the management of obesity

  • Donna H. Ryan


Drugs that act through noradrenergic and serotonergic mechanisms have historically served as the mainstays of pharmacologic treatments for obesity. This review addresses the following three topics: a brief discussion of older weight loss medications approved for short-term use (benzphetamine, phendimetrazine, diethylpropion, mazindol, and phentermine), as well as over-the-counter adrenergic drugs (phenylpro-panolamine and ephedrine); recent clinical studies documenting the safety and efficacy of a new medication for obesity treatment, sibutramine, recently approved by the Food and Drug Administration for long-term use; and recent studies characterizing the valvulopathy associated with fenfluramine and dexfenfluramine, serotonergic medications for obesity which have been removed from the markets.

Key Words

Anorexiant valvulopathy pharmacotherapy noredrenergic serotonergic sibutremine 


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Copyright information

© Human Press Inc 2000

Authors and Affiliations

  1. 1.Pennington Biomedical Research CenterBaton Rouge

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